Examining the cooperativity mode of antibody and CD8 + T cell immune responses for vaccinology

Bocharov, Gennady A.; Grebennikov, Dmitry; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas

doi:http://dx.doi.org/10.1016/j.it.2021.08.003

Examining the cooperativity mode of antibody and CD8 + T cell immune responses for vaccinology

Citation

Bocharov G, Grebennikov D, Argilaguet J, Meyerhans A. Examining the cooperativity mode of antibody and CD8 + T cell immune responses for vaccinology. Trends Immunol. 2021 Oct;42(10):852-855. DOI: 10.1016/j.it.2021.08.003

Abstract

A fundamental unsolved issue in vaccine design is how neutralizing antibodies and cytotoxic CD8+ T cells cooperate numerically in controlling virus infections. We hypothesize on a viewpoint for the multiplicative cooperativity between neutralizing antibodies and CD8+ T cells and propose how this might be exploited for improving vaccine-induced protective immunity.