Toward naturalistic neuroscience: Mechanisms underlying the flattening of brain hierarchy in movie-watching compared to rest and task

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• dc.contributor.author Kringelbach, Morten L.
• dc.contributor.author Sanz Perl, Yonatan
• dc.contributor.author Tagliazucchi, Enzo
• dc.contributor.author Deco, Gustavo
• dc.date.accessioned 2023-03-20T07:18:42Z
• dc.date.available 2023-03-20T07:18:42Z
• dc.date.issued 2023
• dc.description.abstract Identifying the functional specialization of the brain has moved from using cognitive tasks and resting state to using ecological relevant, naturalistic movies. We leveraged a large-scale neuroimaging dataset to directly investigate the hierarchical reorganization of functional brain activity when watching naturalistic films compared to performing seven cognitive tasks and resting. A thermodynamics-inspired whole-brain model paradigm revealed the generative underlying mechanisms for changing the balance in causal interactions between brain regions in different conditions. Paradoxically, the hierarchy is flatter for movie-watching, and the level of nonreversibility is significantly smaller in comparison to both rest and tasks, where the latter in turn have the highest levels of hierarchy and nonreversibility. The underlying mechanisms were revealed by the model-based generative effective connectivity (GEC). Naturalistic films could therefore provide a fast and convenient way to measure important changes in GEC (integrating functional and anatomical connectivity) found in, for example, neuropsychiatric disorders. Overall, this study demonstrates the benefits of moving toward a more naturalistic neuroscience.
• dc.description.sponsorship G.D. is supported by the Human Brain Project Specific Grant Agreement 3 Grant agreement no. 945539 and by the Spanish Research Project AWAKENING: Using whole-brain models perturbational approaches for predicting external stimulation to force transitions between different brain states, ref. PID2019-105772GB-I00/AEI/10.13039/501100011033, financed by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI). Y.S.P. is supported by European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant 896354. E.T. is supported by grants PICT-2018-03103 and PICT-2019-02294 funded by Agencia I+D+I (Argentina) and by a Mercator fellowship granted by the German Research Foundation. M.L.K. is supported by the Centre for Eudaimonia and Human Flourishing (funded by the Pettit and Carlsberg Foundations) and Center for Music in the Brain (funded by the Danish National Research Foundation, DNRF117).
• dc.format.mimetype application/pdf
• dc.identifier.citation Kringelbach ML, Sanz Y, Tagliazucchi E, Deco G. Toward naturalistic neuroscience: Mechanisms underlying the flattening of brain hierarchy in movie-watching compared to rest and task. Sci Adv. 2023 Jan 13;9(2):eade6049. DOI: 10.1126/sciadv.ade6049
• dc.identifier.doi http://dx.doi.org/10.1126/sciadv.ade6049
• dc.identifier.issn 2375-2548
• dc.identifier.uri http://hdl.handle.net/10230/56265
• dc.language.iso eng
• dc.publisher American Association for the Advancement of Science (AAAS)
• dc.relation.ispartof Science Advances. 2023 Jan 13;9(2):eade6049
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/896354
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-105772GB-I00
• dc.rights © 2023 The Authors, some rights reserved; exclusive license American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.other Neurociència cognitiva
• dc.subject.other Neurociències
• dc.subject.other Neurociència afectiva
• dc.title Toward naturalistic neuroscience: Mechanisms underlying the flattening of brain hierarchy in movie-watching compared to rest and task
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion