SYLVIUS: A multimodal and multidisciplinary platform for epilepsy surgery

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• dc.contributor.author Higueras-Esteban, Alfredo
• dc.contributor.author Delgado-Martínez, Ignacio
• dc.contributor.author Serrano, Laura
• dc.contributor.author Principe, Alessandro
• dc.contributor.author Pérez Enríquez, Carmen
• dc.contributor.author González Ballester, Miguel Ángel, 1973-
• dc.contributor.author Rocamora Zúñiga, Rodrigo Alberto
• dc.contributor.author Conesa Bertrán, Gerardo
• dc.contributor.author Serra, Luis
• dc.date.accessioned 2021-04-19T08:24:53Z
• dc.date.issued 2021
• dc.description.abstract Background and objective: We present SYLVIUS, a software platform intended to facilitate and improve the complex workflow required to diagnose and surgically treat drug-resistant epilepsies. In complex epilepsies, additional invasive information from exploration with stereoencephalography (SEEG) with deep electrodes may be needed, for which the input from different diagnostic methods and clinicians from several specialties is required to ensure diagnostic efficacy and surgical safety. We aim to provide a software platform with optimal data flow among the different stages of epilepsy surgery to provide smooth and integrated decision making. Methods: The SYLVIUS platform provides a clinical workflow designed to ensure seamless and safe patient data sharing across specialities. It integrates tools for stereo visualization, data registration, transfer of electrode plans referred to distinct datasets, automated postoperative contact segmentation, and novel DWI tractography analysis. Nineteen cases were retrospectively evaluated to track modifications from an initial plan to obtain a final surgical plan, using SYLVIUS. Results: The software was used to modify trajectories in all 19 consulted cases, which were then imported into the robotic system for the surgical intervention. When available, SYLVIUS provided extra multimodal information, which resulted in a greater number of trajectory modifications. Conclusions: The architecture presented in this paper streamlines epilepsy surgery allowing clinicians to have a digital clinical tool that allows recording of the different stages of the procedure, in a common multimodal 2D/3D setting for participation of different clinicians in defining and validating surgical plans for SEEG cases.
• dc.description.sponsorship We would like to thank “la Caixa” Banking Foundation for supporting the project. We would also like to thank the epilepsy clinical staff of the Hospital del Mar (Barcelona, Spain) for their guidance and collaboration throughout the project.
• dc.format.mimetype application/pdf
• dc.identifier.citation Higueras-Esteban A, Delgado-Martínez I, Serrano L, Principe A, Pérez Enriquez C, González Ballester MA, Rocamora R, Conesa G, Serra L. SYLVIUS: A multimodal and multidisciplinary platform for epilepsy surgery. Comput Methods Programs Biomed. 2021;203:106042. DOI: 10.1016/j.cmpb.2021.106042
• dc.identifier.doi http://dx.doi.org/10.1016/j.cmpb.2021.106042
• dc.identifier.issn 0169-2607
• dc.identifier.uri http://hdl.handle.net/10230/47148
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Computer Methods and Programs in Biomedicine. 2021;203:106042
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.cmpb.2021.106042
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Epilepsy surgery
• dc.subject.keyword Stereotactic electroencephalography (SEEG)
• dc.subject.keyword Diffusion-weighted imaging (DWI)
• dc.subject.keyword Surgical workflow
• dc.subject.keyword Multimodal
• dc.subject.keyword Multidisciplinary
• dc.title SYLVIUS: A multimodal and multidisciplinary platform for epilepsy surgery
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion