Timing of exercise differentially impacts adipose tissue gain in male adolescent rats
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- dc.contributor.author Kutsenko, Yevheniy
- dc.contributor.author Iñiguez, Luis P.
- dc.contributor.author Barreda, Alberto
- dc.contributor.author Pardo Marín, Luis
- dc.contributor.author Toval, Angel
- dc.contributor.author Garrigós, Daniel
- dc.contributor.author Martínez Morga, Marta
- dc.contributor.author Pujante, Santiago
- dc.contributor.author Ribeiro Do-Couto, Bruno
- dc.contributor.author Tseng, Kueiyuan
- dc.contributor.author Cerón, José J.
- dc.contributor.author Garaulet, Marta
- dc.contributor.author Wiśniewska, Marta Barbara
- dc.contributor.author Irimia Martínez, Manuel
- dc.contributor.author Ferrán, José Luis E.
- dc.date.accessioned 2025-02-21T07:14:29Z
- dc.date.available 2025-02-21T07:14:29Z
- dc.date.issued 2025
- dc.description.abstract Objective: Circadian rhythms of metabolic, hormonal, and behavioral fluctuations and their alterations can impact health. An important gap in knowledge in the field is whether the time of the day of exercise and the age of onset of exercise exert distinct effects at the level of whole-body adipose tissue and body composition. The goal of the present study was to determine how exercise at different times of the day during adolescence impacts the adipose tissue transcriptome and content in a rodent model. Methods: Rats were subjected to one of four conditions during their adolescence: early active phase control or exercise (EAC or EAE; ZT13), and late active phase control or exercise (LAC or LAE; ZT23). The effects of exercise timing were assessed at the level of subcutaneous and visceral adipose tissue transcriptome, body composition, hypothalamic expression of orexigenic and anorexigenic genes, blood serum markers and 24-hour core body temperature patterns. Results: We found that late active phase exercise (ZT23) greatly upregulated pathways of lipid synthesis, glycolysis and NADH shuttles in LAE rats, compared to LAC or EAE. Conversely, LAE rats showed notably lower content of adipose tissue. In addition, LAE rats showed signs of impaired FGF21-adiponectin axis compared to other groups. Conclusions: Finally, LAE rats showed higher post-exercise core body temperature compared to other groups. Our results thus indicate that our exercise protocol induced an unusual effect characterized by enhanced lipid synthesis but reduced adipose tissue content in late active phase but not early active phase exercise during adolescence.
- dc.format.mimetype application/pdf
- dc.identifier.citation Kutsenko Y, Iñiguez LP, Barreda A, Pardo-Marín L, Toval A, Garrigos D, et al. Timing of exercise differentially impacts adipose tissue gain in male adolescent rats. Mol Metab. 2025 Jan 18;93:102100. DOI: 10.1016/j.molmet.2025.102100
- dc.identifier.doi http://dx.doi.org/10.1016/j.molmet.2025.102100
- dc.identifier.issn 2212-8778
- dc.identifier.uri http://hdl.handle.net/10230/69670
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Mol Metab. 2025 Jan 18;93:102100
- dc.rights © 2025 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Adipose tissue
- dc.subject.keyword Adolescence
- dc.subject.keyword Body composition
- dc.subject.keyword Circadian system
- dc.subject.keyword Forced exercise
- dc.subject.keyword Rodent
- dc.subject.keyword Transcriptomics
- dc.title Timing of exercise differentially impacts adipose tissue gain in male adolescent rats
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion