Locomotion-related oscillatory body movements at 6-12 Hz modulate the hippocampal theta rhythm

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• dc.contributor.author Ledberg, Andersca
• dc.contributor.author Robbe, Davidca
• dc.date.accessioned 2016-02-17T13:43:23Z
• dc.date.available 2016-02-17T13:43:23Z
• dc.date.issued 2011
• dc.description.abstract The hippocampal theta rhythm is required for accurate navigation and spatial memory but its relation to the dynamics of/nlocomotion is poorly understood. We used miniature accelerometers to quantify with high temporal and spatial resolution/nthe oscillatory movements associated with running in rats. Simultaneously, we recorded local field potentials in the CA1/narea of the hippocampus. We report that when rats run their heads display prominent vertical oscillations with frequencies/nin the same range as the hippocampal theta rhythm (i.e., 6–12 Hz). In our behavioral set-up, rats run mainly with speeds/nbetween 50 and 100 cm/s. In this range of speeds, both the amplitude and frequency of the ‘‘theta’’ head oscillations were/nincreasing functions of running speed, demonstrating that the head oscillations are part of the locomotion dynamics. We/nfound evidence that these rhythmical locomotor dynamics interact with the neuronal activity in the hippocampus. The/namplitude of the hippocampal theta rhythm depended on the relative phase shift with the head oscillations, being maximal/nwhen the two signals were in phase. Despite similarity in frequency, the head movements and LFP oscillations only/ndisplayed weak phase and frequency locking. Our results are consistent with that neurons in the CA1 region receive inputs/nthat are phase locked to the head acceleration signal and that these inputs are integrated with the ongoing theta rhythm.ca
• dc.description.sponsorship This work was funded by a national grant from the Ministerio de Ciencia e Innovación (BFU2008-03946, to D.R.) and a Marie Curie International Reintegration Grant (IRG230976 to D.R.). A.L. and D.R. were supported by Ramon-Y-Cajal fellowships from the Ministerio de Ciencia e Innovación. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Ledberg A, Robbe D. Locomotion-related oscillatory body movements at 6–12 Hz modulate the hippocampal theta rhythm. Plos One. 2011;6(1):1-10. DOI: 10.1371/journal.pone.0027575.
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0027575
• dc.identifier.issn 1932-6203
• dc.identifier.uri http://hdl.handle.net/10230/25856
• dc.language.iso engca
• dc.publisher Public Library of Scienceca
• dc.relation.ispartof Plos One. 2011;6(1):1-10
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2008-03946
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/230976
• dc.rights © 2011 Ledberg, Robbe. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits/nunrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.title Locomotion-related oscillatory body movements at 6-12 Hz modulate the hippocampal theta rhythmca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca