Reduced variability of ongoing and evoked cortical activity leads to improved behavioral performance
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- dc.contributor.author Ledberg, Andersca
- dc.contributor.author Montagnini, Annaca
- dc.contributor.author Coppola, Richardca
- dc.contributor.author Bressler, Sreven L.ca
- dc.date.accessioned 2016-02-17T14:34:32Z
- dc.date.available 2016-02-17T14:34:32Z
- dc.date.issued 2012
- dc.description.abstract Sensory responses of the brain are known to be highly variable, but the origin and functional relevance of this variability/nhave long remained enigmatic. Using the variable foreperiod of a visual discrimination task to assess variability in the/nprimate cerebral cortex, we report that visual evoked response variability is not only tied to variability in ongoing cortical/nactivity, but also predicts mean response time. We used cortical local field potentials, simultaneously recorded from/nwidespread cortical areas, to gauge both ongoing and visually evoked activity. Trial-to-trial variability of sensory evoked/nresponses was strongly modulated by foreperiod duration and correlated both with the cortical variability before stimulus/nonset as well as with response times. In a separate set of experiments we probed the relation between small saccadic eye/nmovements, foreperiod duration and manual response times. The rate of eye movements was modulated by foreperiod/nduration and eye position variability was positively correlated with response times. Our results indicate that when the time/nof a sensory stimulus is predictable, reduction in cortical variability before the stimulus can improve normal behavioral/nfunction that depends on the stimulus.ca
- dc.description.sponsorship The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007–2013) under grant agreement no. 269921 (BrainScaleS). AL is supported by the Ramon y Cajal program from the Spanish government. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Ledberg A, Montagnini A, Coppola R, Bressler SL. Reduced variability of ongoing and evoked cortical activity leads to improved behavioral performance. PLoS ONE. 2012;7(8):1-10. DOI: 10.1371/journal.pone.0043166.
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0043166
- dc.identifier.issn 1932-6203
- dc.identifier.uri http://hdl.handle.net/10230/25859
- dc.language.iso engca
- dc.publisher Public Library of Scienceca
- dc.relation.ispartof PLoS ONE. 2012;7(8):1-10.
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/269921
- dc.rights © 2012 Ledberg et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits/nunrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.title Reduced variability of ongoing and evoked cortical activity leads to improved behavioral performanceca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca