Pharmacokinetic Comparison of Soy Isoflavone Extracts in Human Plasma.
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- dc.contributor.author Rodríguez-Morató, Jose, 1987-ca
- dc.contributor.author Farré Albaladejo, Magíca
- dc.contributor.author Pérez Mañá, Claraca
- dc.contributor.author Papaseit Fontanet, Estherca
- dc.contributor.author Martínez Riera, Roserca
- dc.contributor.author Torre Fornell, Rafael de laca
- dc.contributor.author Pizarro Lozano, Mª Nievesca
- dc.date.accessioned 2015-11-02T08:19:39Z
- dc.date.available 2016-08-31T02:00:04Z
- dc.date.issued 2015
- dc.description.abstract The soy isoflavones daidzein and genistein produce several biological activities related to health benefits. A number of isoflavone extracts are commercially available, but there is little information concerning the specific isoflavone content of these products or differences in their bioavailability and pharmacokinetics. This study describes the development and validation of an analytical method to detect and quantify daidzein, genistein, and equol in human plasma using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The method was applied in a crossover, randomized, bioavailability study. Twelve healthy volunteers were administered the same total isoflavones dose from two isoflavone supplement preparations (Super-Absorbable Soy Isoflavones (Life Extension, USA) and Fitoladius (Merck, Spain)). The pharmacokinetic parameters (AUC0-24/dose and Cmax/dose) of the isoflavones from the two preparations differed significantly. Such differences in bioavailability and kinetics may have relevant effects on the health benefits derived from their intake.ca
- dc.description.sponsorship Funded by grants from the Ministerio de Sanidad (Investigación Clínica Independiente, EC-10-166), Fondo de Investigación Sanitaria-ISCIII-FEDER RTA (RD12/0028/0009), CIBEROBN (CB06/03/0028), Generalitat de Catalunya (AGAUR 2014SGR680, predoctoral fellowship FI-DGR 2013 for JRM) and PN I+D+I 2008-2011 and ISCIII CA11/00215 for NP. CPM and EP are Rio Hortega fellows (ISC-III, CM12/00085 and CM13/00016). The author's work was independent of the sources of funding.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Rodríguez-Morató J, Farré M, Pérez-Mañá C, Papaseit E, Martínez-Riera R, de la Torre R. et al. Pharmacokinetic comparison of soy isoflavone extracts in human plasma. J Agric Food Chem. 2015 Aug 12;63(31):6946-53. DOI: 10.1021/acs.jafc.5b02891ca
- dc.identifier.doi http://dx.doi.org/10.1021/acs.jafc.5b02891
- dc.identifier.issn 0021-8561
- dc.identifier.uri http://hdl.handle.net/10230/24977
- dc.language.iso engca
- dc.publisher ACS Publicationsca
- dc.relation.ispartof Journal of Agricultural and Food Chemistry. 2015 Aug 12;63(31):6946-53
- dc.rights This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal Of Agricultural And Food Chemistry , copyright © American Chemical Society after peer review and technical editing by the publisher./nTo access the final edited and published work see http://dx.doi.org/10.1021/acs.jafc.5b02891ca
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Soy isoflavone extracts
- dc.subject.keyword Daidzein
- dc.subject.keyword Genistein
- dc.subject.keyword Equol
- dc.subject.keyword Bioavailability
- dc.subject.keyword Pharmacokinetics
- dc.subject.keyword Clinical trial
- dc.title Pharmacokinetic Comparison of Soy Isoflavone Extracts in Human Plasma.ca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca