Pharmacokinetic Comparison of Soy Isoflavone Extracts in Human Plasma.

Rodríguez-Morató, Jose, 1987-; Farré Albaladejo, Magí; Pérez Mañá, Clara; Papaseit Fontanet, Esther; Martínez  Riera, Roser; Torre Fornell, Rafael de la; Pizarro Lozano, Mª Nieves

doi:http://dx.doi.org/10.1021/acs.jafc.5b02891

Pharmacokinetic Comparison of Soy Isoflavone Extracts in Human Plasma.

Citation

Rodríguez-Morató J, Farré M, Pérez-Mañá C, Papaseit E, Martínez-Riera R, de la Torre R. et al. Pharmacokinetic comparison of soy isoflavone extracts in human plasma. J Agric Food Chem. 2015 Aug 12;63(31):6946-53. DOI: 10.1021/acs.jafc.5b02891

Abstract

The soy isoflavones daidzein and genistein produce several biological activities related to health benefits. A number of isoflavone extracts are commercially available, but there is little information concerning the specific isoflavone content of these products or differences in their bioavailability and pharmacokinetics. This study describes the development and validation of an analytical method to detect and quantify daidzein, genistein, and equol in human plasma using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The method was applied in a crossover, randomized, bioavailability study. Twelve healthy volunteers were administered the same total isoflavones dose from two isoflavone supplement preparations (Super-Absorbable Soy Isoflavones (Life Extension, USA) and Fitoladius (Merck, Spain)). The pharmacokinetic parameters (AUC0-24/dose and Cmax/dose) of the isoflavones from the two preparations differed significantly. Such differences in bioavailability and kinetics may have relevant effects on the health benefits derived from their intake.