A rule-based method to model myocardial fiber orientation in cardiac biventricular geometries with outflow tracts
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Doste Beltrán, Rubén
- dc.contributor.author Soto-Iglesias, David
- dc.contributor.author Bernardino Perez, Gabriel
- dc.contributor.author Alcaine, Alejandro
- dc.contributor.author Sebastián Aguilar, Rafael, 1978-
- dc.contributor.author Giffard-Roisin, Sophie
- dc.contributor.author Sermesant, Maxime
- dc.contributor.author Berruezo Sánchez, Antonio
- dc.contributor.author Sánchez-Quintana, Damián
- dc.contributor.author Camara, Oscar
- dc.date.accessioned 2019-11-22T15:25:03Z
- dc.date.issued 2019
- dc.description.abstract Rule-based methods are often used for assigning fiber orientation to cardiac anatomical models. However, existing methods have been developed using data mostly from the left ventricle. As a consequence, fiber information obtained from rule-based methods often does not match histological data in other areas of the heart such as the right ventricle, having a negative impact in cardiac simulations beyond the left ventricle. In this work, we present a rule-based method where fiber orientation is separately modeled in each ventricle following observations from histology. This allows to create detailed fiber orientation in specific regions such as the endocardium of the right ventricle, the interventricular septum and the outflow tracts. We also carried out electrophysiological simulations involving these structures and with different fiber configurations. In particular, we built a modelling pipeline for creating patient-specific volumetric meshes of biventricular geometries, including the outflow tracts, and subsequently simulate the electrical wavefront propagation in outflow tract ventricular arrhythmias with different origins for the ectopic focus. The resulting simulations with the proposed rule-based method showed a very good agreement with clinical parameters such as the 10 ms isochrone ratio in a cohort of nine patients suffering from this type of arrhythmia. The developed modelling pipeline confirms its potential for an in silico identification of the site of origin in outflow tract ventricular arrhythmias before clinical intervention.en
- dc.description.sponsorship This work was partially funded by the European Union under the Horizon 2020 Programme for Research, Innovation (grant agreement No. 642676 CardioFunXion).en
- dc.format.mimetype application/pdf
- dc.identifier.citation Doste R, Soto-Iglesias D, Bernardino G, Alcaine A, Sebastian R, Giffard-Roisin S, Sermesant M, Berruezo A,Sanchez-Quintana D,Camara O. A rule-based method to model myocardial fiber orientation in cardiac biventricular geometries with outflow tracts. Int J Numer Method Biomed Eng. 2019 Feb 05;35(4):e3185. DOI: 10.1002/cnm.3185
- dc.identifier.doi http://dx.doi.org/10.1002/cnm.3185
- dc.identifier.issn 2040-7939
- dc.identifier.uri http://hdl.handle.net/10230/42943
- dc.language.iso eng
- dc.publisher Wiley
- dc.relation.ispartof International Journal for Numerical Methods in Biomedical Engineering. 2019 Feb 05;35(4):e3185
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/642676
- dc.rights This is the peer reviewed version of the following article: Doste R, Soto-Iglesias D, Bernardino G, Alcaine A, Sebastian R, Giffard-Roisin S, Sermesant M, Berruezo A,Sanchez-Quintana D,Camara O. A rule-based method to model myocardial fiber orientation in cardiac biventricular geometries with outflow tracts. Title Abbreviation: Int J Numer Method Biomed Eng. 2019 Feb 05;35(4):e3185, which has been published in final form at https://doi.org/10.1002/cnm.3185 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Rule-based methoden
- dc.subject.keyword Fiber orientationen
- dc.subject.keyword Outflow tracten
- dc.subject.keyword Septumen
- dc.subject.keyword Electrophysiological simulationsen
- dc.subject.keyword Outflow tract ventricular arrhythmiaen
- dc.title A rule-based method to model myocardial fiber orientation in cardiac biventricular geometries with outflow tractsen
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion