Cortico-cortical communication dynamics
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- dc.contributor.author Roland, Per E.ca
- dc.contributor.author Hilgetag, Claus C.ca
- dc.contributor.author Deco, Gustavoca
- dc.date.accessioned 2016-02-16T14:34:25Z
- dc.date.available 2016-02-16T14:34:25Z
- dc.date.issued 2014
- dc.description.abstract In principle, cortico-cortical communication dynamics is simple: neurons in one cortical area communicate by sending action potentials that release glutamate and excite their target neurons in other cortical areas. In practice, knowledge about cortico-cortical communication dynamics is minute. One reason is that no current technique can capture the fast spatio-temporal cortico-cortical evolution of action potential transmission and membrane conductances with sufficient spatial resolution. A combination of optogenetics and monosynaptic tracing with virus can reveal the spatio-temporal cortico-cortical dynamics of specific neurons and their targets, but does not reveal how the dynamics evolves under natural conditions. Spontaneous ongoing action potentials also spread across cortical areas and are difficult to separate from structured evoked and intrinsic brain activity such as thinking. At a certain state of evolution, the dynamics may engage larger populations of neurons to drive the brain to decisions, percepts and behaviors. For example, successfully evolving dynamics to sensory transients can appear at the mesoscopic scale revealing how the transient is perceived. As a consequence of these methodological and conceptual difficulties, studies in this field comprise a wide range of computational models, large-scale measurements (e.g., by MEG, EEG), and a combination of invasive measurements in animal experiments. Further obstacles and challenges of studying cortico-cortical communication dynamics are outlined in this critical review.ca
- dc.description.sponsorship Claus C. Hilgetag is supported by DFG grants HI 1286/5-1 and/nSFB 936/A1. Per E. Roland is supported by The Danish Ministry/nfor Science and Innovations through FSS, and the University/nof Copenhagen 2016 funds through the Dynamical Systems/nInterdisciplinary Network
- dc.format.mimetype application/pdfca
- dc.identifier.citation Roland PE, Hilgetag CC, Deco G. Cortico-cortical communication dynamics. Frontiers in Neuroscience. 2014;19(8):1-11. DOI: 10.3389/fnsys.2014.00019.
- dc.identifier.doi http://dx.doi.org/10.3389/fnsys.2014.00019
- dc.identifier.issn 1662-4548
- dc.identifier.uri http://hdl.handle.net/10230/25836
- dc.language.iso engca
- dc.publisher Frontiers Mediaca
- dc.relation.ispartof Frontiers in Neuroscience. 2014;19(8):1-11.
- dc.rights © 2014 Roland, Hilgetag and Deco. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/3.0/ca
- dc.subject.keyword Spontaneous activity
- dc.subject.keyword Synaptic transmission
- dc.subject.keyword Membrane potential dynamics
- dc.subject.keyword Spiking dynamics
- dc.subject.keyword Cortical areas
- dc.title Cortico-cortical communication dynamicsca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca