The eTRANSAFE project on translational safety assessment through integrative knowledge management: achievements and perspectives

Pognan, François; Centeno, Emilio; Furlong, Laura I., 1971-; Guney, Emre; Mayer, Miguel Ángel, 1960-; Pastor Maeso, Manuel; Piñero González, Janet, 1977-; Ramírez Anguita, Juan Manuel; Ronzano, Francesco; Saüch Pitarch, Josep; Sanz, Ferran

doi:http://dx.doi.org/10.3390/ph14030237

The eTRANSAFE project on translational safety assessment through integrative knowledge management: achievements and perspectives

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Pognan F, Steger-Hartmann T, Díaz C, Blomberg N, Bringezu F, Briggs K et al. The eTRANSAFE project on translational safety assessment through integrative knowledge management: achievements and perspectives. Pharmaceuticals (Basel). 2021; 14(3):237. DOI: 10.3390/ph14030237

Abstract

eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety assessment of new drugs by using legacy data provided by the pharmaceutical companies that participate in the project. The project objectives include the development of databases containing preclinical and clinical data, computational systems for translational analysis including tools for data query, analysis and visualization, as well as computational models to explain and predict drug safety events.