Musculoskeletal modeling of the lumbar spine to explore functional interactions between back muscle loads and intervertebral disk multiphysics

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• dc.contributor.author Toumanidou, Themis
• dc.contributor.author Noailly, Jérôme
• dc.date.accessioned 2025-01-20T07:30:13Z
• dc.date.available 2025-01-20T07:30:13Z
• dc.date.issued 2015
• dc.description.abstract During daily activities, complex biomechanical interactions influence the biophysical regulation of intervertebral disks (IVDs), and transfers of mechanical loads are largely controlled by the stabilizing action of spine muscles. Muscle and other internal forces cannot be easily measured directly in the lumbar spine. Hence, biomechanical models are important tools for the evaluation of the loads in those tissues involved in low-back disorders. Muscle force estimations in most musculoskeletal models mainly rely, however, on inverse calculations and static optimizations that limit the predictive power of the numerical calculations. In order to contribute to the development of predictive systems, we coupled a predictive muscle model with the passive resistance of the spine tissues, in a L3–S1 musculoskeletal finite element model with osmo-poromechanical IVD descriptions. The model included 46 fascicles of the major back muscles that act on the lower spine. The muscle model interacted with activity-related loads imposed to the osteoligamentous structure, as standing position and night rest were simulated through distributed upper body mass and free IVD swelling, respectively. Calculations led to intradiscal pressure values within ranges of values measured in vivo. Disk swelling led to muscle activation and muscle force distributions that seemed particularly appropriate to counterbalance the anterior body mass effect in standing. Our simulations pointed out a likely existence of a functional balance between stretch-induced muscle activation and IVD multiphysics toward improved mechanical stability of the lumbar spine understanding. This balance suggests that proper night rest contributes to mechanically strengthen the spine during day activity.en
• dc.description.sponsorship Financial funding from the European Commission (MySpine FP7-ICT-269909) is acknowledged. The authors are also grateful to Dr. Gerard Fortuny from the Universitat Rovira i Virgili for his recommendations about the initial choice of the muscle constitutive model components.
• dc.format.mimetype application/pdf
• dc.identifier.citation Toumanidou T, Noailly J. Musculoskeletal modeling of the lumbar spine to explore functional interactions between back muscle loads and intervertebral disk multiphysics. Front Bioeng Biotechnol. 2015 Aug 5;3:111. DOI: 10.3389/fbioe.2015.00111
• dc.identifier.doi http://dx.doi.org/10.3389/fbioe.2015.00111
• dc.identifier.issn 2296-4185
• dc.identifier.uri http://hdl.handle.net/10230/69174
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Frontiers in Bioengineering and Biotechnology. 2015 Aug 5;3:111
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/269909
• dc.rights © 2015 Toumanidou and Noailly. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Constitutive muscle modelen
• dc.subject.keyword Lumbar spine finite element modelen
• dc.subject.keyword Intervertebral disk swellingen
• dc.subject.keyword Intervertebral disk–muscle interactionen
• dc.subject.keyword Standingen
• dc.subject.keyword Night resten
• dc.title Musculoskeletal modeling of the lumbar spine to explore functional interactions between back muscle loads and intervertebral disk multiphysicsen
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion