Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson’s disease

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  • dc.contributor.author Saenger Amoore, Victor Manuel
  • dc.contributor.author Kahan, Joshua
  • dc.contributor.author Foltynie, Tom
  • dc.contributor.author Friston, Karl
  • dc.contributor.author Aziz, Tipu Z.
  • dc.contributor.author Green, Alex L.
  • dc.contributor.author Van Hartevelt, Tim J.
  • dc.contributor.author Cabral, Joana
  • dc.contributor.author Stevner, Angus B. A.
  • dc.contributor.author Fernandes, Henrique M.
  • dc.contributor.author Mancini, Laura
  • dc.contributor.author Thornton, John
  • dc.contributor.author Yousry, Tarek
  • dc.contributor.author Limousin, Patricia
  • dc.contributor.author Zrinzo, Ludvic
  • dc.contributor.author Hariz, Marwan
  • dc.contributor.author Marques, Paulo
  • dc.contributor.author Sousa, Nuno
  • dc.contributor.author Kringelbach, Morten L.
  • dc.contributor.author Deco, Gustavo
  • dc.date.accessioned 2019-04-11T10:03:38Z
  • dc.date.available 2019-04-11T10:03:38Z
  • dc.date.issued 2017
  • dc.description.abstract Deep brain stimulation (DBS) for Parkinson’s disease is a highly effective treatment in controlling otherwise debilitating symptoms. Yet the underlying brain mechanisms are currently not well understood. Whole-brain computational modeling was used to disclose the effects of DBS during resting-state functional Magnetic Resonance Imaging in ten patients with Parkinson’s disease. Specifically, we explored the local and global impact that DBS has in creating asynchronous, stable or critical oscillatory conditions using a supercritical bifurcation model. We found that DBS shifts global brain dynamics of patients towards a Healthy regime. This effect was more pronounced in very specific brain areas such as the thalamus, globus pallidus and orbitofrontal regions of the right hemisphere (with the left hemisphere not analyzed given artifacts arising from the electrode lead). Global aspects of integration and synchronization were also rebalanced. Empirically, we found higher communicability and coherence brain measures during DBS-ON compared to DBS-OFF. Finally, using our model as a framework, artificial in silico DBS was applied to find potential alternative target areas for stimulation and whole-brain rebalancing. These results offer important insights into the underlying large-scale effects of DBS as well as in finding novel stimulation targets, which may offer a route to more efficacious treatments.
  • dc.description.sponsorship In this work, Gustavo Deco is supported by the ERC Advanced Grant: DYSTRUCTURE (n. 295129), by the Spanish Research Project PSI2016-75688-P and by the the European Union’s Horizon 2020 research and innovation programme under grant agreement n. 720270 (HBP SGA1). Morten Kringelbach is supported by the ERC Consolidator Grant CAREGIVING (n. 615539) and the Center for Music in the Brain, funded by the Danish National Research Foundation (DNRF117). Victor M Saenger is supported by the Research Personnel Training program PSI2013-42091-P funded by the Spanish Ministry of Economy and Competitiveness.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Saenger VM, Kahan J, Foltynie T, Friston K, Aziz TZ, Green AL, Van Hartevelt TJ, Cabral J, Stevner ABA, Fernandes HM, Mancini L, Thornton J, Yousry T, Limousin P, Zrinzo L, Hariz M, Marques P, Sousa N, Kringelbach ML, Deco G. Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson’s disease. Sci Rep. 2017 Aug 29;7(1):9882. DOI: 10.1038/s41598-017-10003-y
  • dc.identifier.doi http://dx.doi.org/10.1038/s41598-017-10003-y
  • dc.identifier.issn 2045-2322
  • dc.identifier.uri http://hdl.handle.net/10230/37092
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.relation.ispartof Scientific Reports. 2017 Aug 29;7(1):9882.
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/295129
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/720270
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2016-75688-P
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/615539
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2013-42091-P
  • dc.rights © This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Dynamical systems
  • dc.subject.keyword Parkinson's disease
  • dc.title Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson’s disease
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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