Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: the earlycause project

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• dc.contributor.author Mariani, Nicole
• dc.contributor.author Buisan, Carme
• dc.contributor.author González Ballester, Miguel Ángel, 1973-
• dc.contributor.author Piella Fenoy, Gemma
• dc.contributor.author Lekadir, Karim, 1977-
• dc.date.accessioned 2021-03-15T08:14:18Z
• dc.date.available 2021-03-15T08:14:18Z
• dc.date.issued 2021
• dc.description.abstract Introduction: Depression, cardiovascular diseases and diabetes are among the major non-communicable diseases, leading to significant disability and mortality worldwide. These diseases may share environmental and genetic determinants associated with multimorbid patterns. Stressful early-life events are among the primary factors associated with the development of mental and physical diseases. However, possible causative mechanisms linking early life stress (ELS) with psycho-cardio-metabolic (PCM) multi-morbidity are not well understood. This prevents a full understanding of causal pathways towards the shared risk of these diseases and the development of coordinated preventive and therapeutic interventions. Methods and analysis: This paper describes the study protocol for EarlyCause, a large-scale and inter-disciplinary research project funded by the European Union’s Horizon 2020 research and innovation programme. The project takes advantage of human longitudinal birth cohort data, animal studies and cellular models to test the hypothesis of shared mechanisms and molecular pathways by which ELS shapes an individual’s physical and mental health in adulthood. The study will research in detail how ELS converts into biological signals embedded simultaneously or sequentially in the brain, the cardiovascular and metabolic systems. The research will mainly focus on four biological processes including possible alterations of the epigenome, neuroendocrine system, inflammatome, and the gut microbiome. Life-course models will integrate the role of modifying factors as sex, socioeconomics, and lifestyle with the goal to better identify groups at risk as well as inform promising strategies to reverse the possible mechanisms and/or reduce the impact of ELS on multi-morbidity development in high-risk individuals. These strategies will help better manage the impact of multi-morbidity on human health and the associated risk.
• dc.description.sponsorship This work is supported by the European Union’s Horizon 2020 research and innovation programme (grant n° 848158). The funders had and will not have a role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
• dc.format.mimetype application/pdf
• dc.identifier.citation Mariani N, Borsini A, Cecil CAM, Felix JF, Sebert S, Cattaneo A, et al. Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: the earlycause project. PLoS One. 2021 Jan 21;16(1):e0245475. DOI: 10.1371/journal.pone.0245475
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0245475
• dc.identifier.issn 1932-6203
• dc.identifier.uri http://hdl.handle.net/10230/46767
• dc.language.iso eng
• dc.publisher Public Library of Science (PLoS)
• dc.relation.ispartof PLoS One. 2021 Jan 21;16(1):e0245475
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/848158
• dc.rights © 2021 Mariani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Medical Risk Factors
• dc.subject.keyword Epigenetics
• dc.subject.keyword Psychological Stress
• dc.subject.keyword Depression
• dc.subject.keyword Human genetics
• dc.subject.keyword Metabolics Pathways
• dc.title Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: the earlycause project
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion