A myxoid fibrotic reaction pattern is associated with metastatic risk in cutaneous squamous cell carcinoma

Hernández-Ruiz, Eugenia; Hernández Muñoz, María Inmaculada; Masferrer, Emili; Ferrandiz-Pulido, Carla; Andrades, Evelyn; Gimeno Beltran, Javier; Duran Jordà, Xavier, 1974-; García-Patos, Vicenç; Pujol Vallverdú, Ramón M.; Toll Abelló, Agustín

doi:http://dx.doi.org/10.2340/00015555-3025

A myxoid fibrotic reaction pattern is associated with metastatic risk in cutaneous squamous cell carcinoma

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Hernández-Ruiz E, Hernández-Muñoz I, Masferrer E, Ferrándiz-Pulido C, Andrades E, Gimeno J, et al. A myxoid fibrotic reaction pattern is associated with metastatic risk in cutaneous squamous cell carcinoma. Acta Derm Venereol. 2019 Jan 1;99(1):89-94. DOI: 10.2340/00015555-3025

Abstract

Although desmoplasia has been associated with poor prognoses in cutaneous squamous cell carcinoma, little attention has been paid to the patterns of fibrosis. This study aimed to examine the different stromal fibrotic patterns as markers of metastatic risk. We performed a multicenter retrospective study that included 102 cutaneous squamous cell carcinomas (52 non-metastatic and 50 metastatic carcinomas). Clinical and histopathological data were registered. The fibrotic reaction pattern was classified as mature, intermediate or immature depending on the presence of keloid-like collagen and myxoid stroma. The immature pattern (areas characterized by myxoid changes with no inflammation) was observed in 18 samples and its presence was significantly associated with immunosuppression, budding, desmoplasia, perineural invasion, anatomic level, tumoural depth and metastatic risk in the multivariate analysis. Our findings suggest that the presence of an immature myxoid fibrotic pattern, which can be easily identified by routine hematoxylin-eosin staining, is strongly associated with metastatic risk.