A myxoid fibrotic reaction pattern is associated with metastatic risk in cutaneous squamous cell carcinoma
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- dc.contributor.author Hernández-Ruiz, Eugenia
- dc.contributor.author Hernández Muñoz, María Inmaculada
- dc.contributor.author Masferrer, Emili
- dc.contributor.author Ferrandiz-Pulido, Carla
- dc.contributor.author Andrades, Evelyn
- dc.contributor.author Gimeno Beltran, Javier
- dc.contributor.author Duran Jordà, Xavier, 1974-
- dc.contributor.author García-Patos, Vicenç
- dc.contributor.author Pujol Vallverdú, Ramon Maria
- dc.contributor.author Toll Abelló, Agustín
- dc.date.accessioned 2019-02-14T08:08:46Z
- dc.date.available 2019-02-14T08:08:46Z
- dc.date.issued 2019
- dc.description.abstract Although desmoplasia has been associated with poor prognoses in cutaneous squamous cell carcinoma, little attention has been paid to the patterns of fibrosis. This study aimed to examine the different stromal fibrotic patterns as markers of metastatic risk. We performed a multicenter retrospective study that included 102 cutaneous squamous cell carcinomas (52 non-metastatic and 50 metastatic carcinomas). Clinical and histopathological data were registered. The fibrotic reaction pattern was classified as mature, intermediate or immature depending on the presence of keloid-like collagen and myxoid stroma. The immature pattern (areas characterized by myxoid changes with no inflammation) was observed in 18 samples and its presence was significantly associated with immunosuppression, budding, desmoplasia, perineural invasion, anatomic level, tumoural depth and metastatic risk in the multivariate analysis. Our findings suggest that the presence of an immature myxoid fibrotic pattern, which can be easily identified by routine hematoxylin-eosin staining, is strongly associated with metastatic risk.
- dc.format.mimetype application/pdf
- dc.identifier.citation Hernández-Ruiz E, Hernández-Muñoz I, Masferrer E, Ferrándiz-Pulido C, Andrades E, Gimeno J, et al. A myxoid fibrotic reaction pattern is associated with metastatic risk in cutaneous squamous cell carcinoma. Acta Derm Venereol. 2019 Jan 1;99(1):89-94. DOI: 10.2340/00015555-3025
- dc.identifier.doi http://dx.doi.org/10.2340/00015555-3025
- dc.identifier.issn 0001-5555
- dc.identifier.uri http://hdl.handle.net/10230/36584
- dc.language.iso eng
- dc.publisher Society for Publication of Acta Dermato-Venereologica
- dc.relation.ispartof Acta Dermato-Venereologica. 2019 Jan 1;99(1):89-94
- dc.rights Journal Compilation © 2019 Acta Dermato-Venereologica. This is an open access article under the CC BY-NC license. www.medicaljournals.se/acta
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
- dc.subject.keyword Metastasis
- dc.subject.keyword Fibrosis
- dc.subject.keyword Cutaneous squamous cell carcinoma.
- dc.subject.other Dermatologia
- dc.title A myxoid fibrotic reaction pattern is associated with metastatic risk in cutaneous squamous cell carcinoma
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion