The multiple usages of Notch signaling in development, cell differentiation and cancer
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- dc.contributor.author Bigas Salvans, Anna
- dc.contributor.author Espinosa Blay, Lluís
- dc.date.accessioned 2019-04-01T07:34:28Z
- dc.date.issued 2018
- dc.description.abstract Notch is a well-conserved signaling pathway all through evolution that is crucial to specify different cell fates. Although there is a strong context dependent component in each decision, the basic mechanisms that originate from the interplay among ligands and receptors is greatly preserved. In this review we will cover the latest findings on the different mechanisms for Notch activation and signaling. The regulation of this pathway is essential to understand development, cell differentiation and disease.
- dc.description.sponsorship We would like to thank Erika López-Arribillaga for help in the figure design and the members of the Bigas and Espinosa lab for help ful discussions. Our research is funded by Ministerio de Economía y Competitividad (SAF2016-75613-R), Fundació AECC (Grupos consolidados),Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) (2017SGR135) and PERIS- (SLT002/16/00299) to AB and Instituto de Salud Carlos III(PI16/00437)to LE.
- dc.format.mimetype application/pdf
- dc.identifier.citation Bigas A, Espinosa L. The multiple usages of Notch signaling in development, cell differentiation and cancer. Curr Opin Cell Biol. 2018 Dec;55:1-7. DOI: 10.1016/j.ceb.2018.06.010
- dc.identifier.doi http://dx.doi.org/10.1016/j.ceb.2018.06.010
- dc.identifier.issn 0955-0674
- dc.identifier.uri http://hdl.handle.net/10230/37012
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Current Opinion in Cell Biology. 2018 Dec;55:1-7
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016-75613-R
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.ceb.2018.06.010
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.other Càncer -- Aspectes genètics
- dc.title The multiple usages of Notch signaling in development, cell differentiation and cancer
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion