The multiple usages of Notch signaling in development, cell differentiation and cancer

Bigas Salvans, Anna; Espinosa Blay, Lluís

doi:http://dx.doi.org/10.1016/j.ceb.2018.06.010

The multiple usages of Notch signaling in development, cell differentiation and cancer

Citation

Bigas A, Espinosa L. The multiple usages of Notch signaling in development, cell differentiation and cancer. Curr Opin Cell Biol. 2018 Dec;55:1-7. DOI: 10.1016/j.ceb.2018.06.010

Abstract

Notch is a well-conserved signaling pathway all through evolution that is crucial to specify different cell fates. Although there is a strong context dependent component in each decision, the basic mechanisms that originate from the interplay among ligands and receptors is greatly preserved. In this review we will cover the latest findings on the different mechanisms for Notch activation and signaling. The regulation of this pathway is essential to understand development, cell differentiation and disease.