Neural geometrodynamics, complexity, and plasticity: a psychedelics perspective

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• dc.contributor.author Ruffini, Giulio
• dc.contributor.author Lopez-Sola, Edmundo
• dc.contributor.author Vohryzek, Jakub
• dc.contributor.author Sanchez Todo, Roser
• dc.date.accessioned 2024-03-19T07:29:55Z
• dc.date.available 2024-03-19T07:29:55Z
• dc.date.issued 2024
• dc.description.abstract We explore the intersection of neural dynamics and the effects of psychedelics in light of distinct timescales in a framework integrating concepts from dynamics, complexity, and plasticity. We call this framework neural geometrodynamics for its parallels with general relativity’s description of the interplay of spacetime and matter. The geometry of trajectories within the dynamical landscape of “fast time” dynamics are shaped by the structure of a differential equation and its connectivity parameters, which themselves evolve over “slow time” driven by state-dependent and state-independent plasticity mechanisms. Finally, the adjustment of plasticity processes (metaplasticity) takes place in an “ultraslow” time scale. Psychedelics flatten the neural landscape, leading to heightened entropy and complexity of neural dynamics, as observed in neuroimaging and modeling studies linking increases in complexity with a disruption of functional integration. We highlight the relationship between criticality, the complexity of fast neural dynamics, and synaptic plasticity. Pathological, rigid, or “canalized” neural dynamics result in an ultrastable confined repertoire, allowing slower plastic changes to consolidate them further. However, under the influence of psychedelics, the destabilizing emergence of complex dynamics leads to a more fluid and adaptable neural state in a process that is amplified by the plasticity-enhancing effects of psychedelics. This shift manifests as an acute systemic increase of disorder and a possibly longer-lasting increase in complexity affecting both short-term dynamics and long-term plastic processes. Our framework offers a holistic perspective on the acute effects of these substances and their potential long-term impacts on neural structure and function.
• dc.description.sponsorship This research was funded by European Commission under European Union’s Horizon 2020 research and innovation programme Grant Number 101017716 (Neurotwin) and European Research Council (ERC Synergy Galvani) under the European Union’s Horizon 2020 research and innovation programme Grant Number 855109.
• dc.format.mimetype application/pdf
• dc.identifier.citation Ruffini G, Lopez-Sola E, Vohryzek J, Sanchez-Todo R. Neural geometrodynamics, complexity, and plasticity: a psychedelics perspective. Entropy. 2024 Jan 22;26(1):90. DOI: 10.3390/e26010090
• dc.identifier.doi http://dx.doi.org/10.3390/e26010090
• dc.identifier.issn 1099-4300
• dc.identifier.uri http://hdl.handle.net/10230/59474
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Entropy. 2024 Jan 22;26(1):90
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/101017716
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/855109
• dc.rights © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Plasticity
• dc.subject.keyword Psychedelics
• dc.subject.keyword Complexity
• dc.title Neural geometrodynamics, complexity, and plasticity: a psychedelics perspective
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion