Reduced spatiotemporal brain dynamics are associated with increased depressive symptoms after a relationship breakup

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• dc.contributor.author Alonso Martínez, Sonsoles
• dc.contributor.author Marsman, Jan-Bernard C.
• dc.contributor.author Kringelbach, Morten L.
• dc.contributor.author Deco, Gustavo
• dc.contributor.author ter Horst, Gert J.
• dc.date.accessioned 2020-07-08T08:35:13Z
• dc.date.available 2020-07-08T08:35:13Z
• dc.date.issued 2020
• dc.description.abstract Depressive symptoms following a stressful life event, such as a relationship breakup, are common, and constitute a potent risk factor for the onset of a major depressive episode. Resting-state neuroimaging studies have increasingly identified abnormal whole-brain communication in patients with depression, but it is currently unclear whether depressive symptoms in individuals without a clinical diagnosis have reliable neural underpinnings. We investigated to what extent the severity of depressive symptoms in a non-clinical sample was associated with imbalances in the complex dynamics of the brain during rest. To this end, a novel intrinsic ignition approach was applied to resting-state neuroimaging data from sixty-nine participants with varying degrees of depressive symptoms following a relationship breakup. Ignition-based measures of integration, hierarchy, and metastability were calculated for each participant, revealing a negative correlation between these measures and depressive ratings. We found that the severity of depressive symptoms was associated with deficits in the brain’s capacity to globally integrate and process information over time. Furthermore, we found that increased depressive symptoms were associated with reduced spatial diversity (i.e., hierarchy) and reduced temporal variability (i.e., metastability) in the functional organization of the brain. These findings suggest the merit of investigating constrained dynamical complexity as it is sensitive to the level of depressive symptoms even in a non-clinical sample.en
• dc.description.sponsorship This work was funded by a donation of Mr. Hazewinkel to Prof. dr. Gert J. ter Horst and the Research School of Behavioural and Cognitive Neurosciences, University of Groningen, the Netherlands. The funder had no role in study design, the collection, analysis and, interpretation of data, the decision to publish, or the writing of the manuscript.
• dc.format.mimetype application/pdf
• dc.identifier.citation Alonso Martínez S, Marsman JBC, Kringelbach ML, Deco G, ter Horst GJ. Reduced spatiotemporal brain dynamics are associated with increased depressive symptoms after a relationship breakup. Neuroimage Clin. 2020 May 26;27:102299. DOI: 10.1016/j.nicl.2020.102299
• dc.identifier.doi http://dx.doi.org/10.1016/j.nicl.2020.102299
• dc.identifier.issn 2213-1582
• dc.identifier.uri http://hdl.handle.net/10230/45088
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof NeuroImage: clinical. 2020 May 26;27:102299
• dc.rights © 2020 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/BY-NC-ND/4.0/
• dc.subject.keyword Resting-state fMRIen
• dc.subject.keyword Global integrationen
• dc.subject.keyword Spatiotemporal dynamicsen
• dc.subject.keyword Whole-brainen
• dc.subject.keyword Depressive symptomsen
• dc.subject.keyword Non-clinical sampleen
• dc.title Reduced spatiotemporal brain dynamics are associated with increased depressive symptoms after a relationship breakupen
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion