The Mismatch negativity as an index of cognitive decline for the early detection of Alzheimer’s disease

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• dc.contributor.author Ruzzoli, Manuelaca
• dc.contributor.author Pirulli, Corneliaca
• dc.contributor.author Mazza, Veronicaca
• dc.contributor.author Miniussi, Carloca
• dc.contributor.author Brignani, Deboraca
• dc.date.accessioned 2018-02-07T15:18:33Z
• dc.date.available 2018-02-07T15:18:33Z
• dc.date.issued 2016
• dc.description.abstract Evidence suggests that Alzheimer's disease (AD) is part of a continuum, characterized by long preclinical phases before the onset of clinical symptoms. In several cases, this continuum starts with a syndrome, defined as mild cognitive impairment (MCI), in which daily activities are preserved despite the presence of cognitive decline. The possibility of having a reliable and sensitive neurophysiological marker that can be used for early detection of AD is extremely valuable because of the incidence of this type of dementia. In this study, we aimed to investigate the reliability of auditory mismatch negativity (aMMN) as a marker of cognitive decline from normal ageing progressing from MCI to AD. We compared aMMN elicited in the frontal and temporal locations by duration deviant sounds in short (400 ms) and long (4000 ms) inter-trial intervals (ITI) in three groups. We found that at a short ITI, MCI showed only the temporal component of aMMN and AD the frontal component compared to healthy elderly who presented both. At a longer ITI, aMMN was elicited only in normal ageing subjects at the temporal locations. Our study provides empirical evidence for the possibility to adopt aMMN as an index for assessing cognitive decline in pathological ageing.
• dc.description.sponsorship This research was supported by a Project grant from Cariplo Foundation and RC “Ministero della Salute”. M.R. was supported by Juan de la Cierva postdoctoral fellowship (JCI-2012–12335) from the Spanish Government.
• dc.format.mimetype application/pdf
• dc.identifier.citation Ruzzoli M, Pirulli C, Mazza V, Miniussi C, Brignani D. The Mismatch negativity as an index of cognitive decline for the early detection of Alzheimer’s disease. Sci rep. 2016;6:33167. DOI: 10.1038/srep33167
• dc.identifier.doi http://dx.doi.org/10.3389/fpsyg.2017.00096
• dc.identifier.issn 2045-2322
• dc.identifier.uri http://hdl.handle.net/10230/33826
• dc.language.iso eng
• dc.publisher Nature Publishing Groupca
• dc.relation.ispartof Science reports. 2016;6:33167.
• dc.rights © The Author(s) 2016 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.title The Mismatch negativity as an index of cognitive decline for the early detection of Alzheimer’s diseaseca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion