Circuit mechanisms for the chemical modulation of cortex-wide network interactions and behavioral variability

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  • dc.contributor.author Pfeffer, Thomas
  • dc.contributor.author Ponce-Alvarez, Adrián
  • dc.contributor.author Tsetsos, Konstantinos
  • dc.contributor.author Meindertsma, Thomas
  • dc.contributor.author Gahnström, Christoffer Julius
  • dc.contributor.author van den Brink, Ruud Lucas
  • dc.contributor.author Nolte, Guido
  • dc.contributor.author Engel, Andreas Karl
  • dc.contributor.author Deco, Gustavo
  • dc.contributor.author Donner, Tobias Hinrich
  • dc.date.accessioned 2022-06-16T06:04:50Z
  • dc.date.available 2022-06-16T06:04:50Z
  • dc.date.issued 2021
  • dc.description.abstract Influential theories postulate distinct roles of catecholamines and acetylcholine in cognition and behavior. However, previous physiological work reported similar effects of these neuromodulators on the response properties (specifically, the gain) of individual cortical neurons. Here, we show a double dissociation between the effects of catecholamines and acetylcholine at the level of large-scale interactions between cortical areas in humans. A pharmacological boost of catecholamine levels increased cortex-wide interactions during a visual task, but not rest. An acetylcholine boost decreased interactions during rest, but not task. Cortical circuit modeling explained this dissociation by differential changes in two circuit properties: the local excitation-inhibition balance (more strongly increased by catecholamines) and intracortical transmission (more strongly reduced by acetylcholine). The inferred catecholaminergic mechanism also predicted noisier decision-making, which we confirmed for both perceptual and value-based choice behavior. Our work highlights specific circuit mechanisms for shaping cortical network interactions and behavioral variability by key neuromodulatory systems.
  • dc.description.sponsorship This work was supported by the Alexander-von-Humboldt Foundation (postdoctoral fellowships to T.P. and R.L.v.d.B.); BMBF 161A130 (to A.K.E.); the Catalan Agencia de Gestión de Ayudas Universitarias Programme 2017 SGR 1545 (to G.D.); the Deutsche Forschungsgemeinschaft (DFG) DO1230/1 and DO1240/1 (to T.H.D.), SFB936/A3 (to A.K.E.), SFB936/A7 (to T.H.D.), and SFB936/Z3 (to G.N. and T.H.D.); the EU Horizon 2020 Research and Innovation Programme under grant agreements 720270 (HBP SGA1) and 785907 (HBP SGA2) (to G.D.); the EU Horizon 2020 Research and Innovation Program, ERC starting grant no. 802905 (to K.T.); the FLAG-ERA JTC (PCI2018-092891) (to A.P.-A.); the International Brain Research Organization (to T.P.); the Netherlands Organization for Scientific Research (NWO, dossiernummer 406-14-016) (to T.H.D.); and the Spanish Research Project PSI2016-75688-P (Agencia Estatal de Investigación/Fondo Europeo de Desarrollo Regional, European Union) (to G.D.); and Deutsche Forschungsgemeinschaft (DFG), TRR169/B4/C1 (to G.N.).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Pfeffer T, Ponce-Alvarez A, Tsetsos K, Meindertsma T, Gahnström CJ, van den Brink RL, Nolte G, Engel AK, Deco G, Donner TH. Circuit mechanisms for the chemical modulation of cortex-wide network interactions and behavioral variability. Sci Adv. 2021;7(29):eabf5620. DOI: 10.1126/sciadv.abf5620
  • dc.identifier.doi http://doi.org/10.1126/sciadv.abf5620
  • dc.identifier.issn 2375-2548
  • dc.identifier.uri http://hdl.handle.net/10230/53501
  • dc.language.iso eng
  • dc.publisher American Association for the Advancement of Science (AAAS)
  • dc.relation.ispartof Science Advances. 2021;7(29):eabf5620
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/720270
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/785907
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/802905
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2016-75688-P
  • dc.rights © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri https://creativecommons.org/licenses/by-nc/4.0
  • dc.subject.other Còrtex cerebral
  • dc.subject.other Cognició
  • dc.title Circuit mechanisms for the chemical modulation of cortex-wide network interactions and behavioral variability
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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