Sensory-motor cortices shape functional connectivity dynamics in the human brain

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• dc.contributor.author Kong, Xiaolu
• dc.contributor.author Kong, Ru
• dc.contributor.author Orban, Csaba
• dc.contributor.author Wang, Peng
• dc.contributor.author Zhang, Shaoshi
• dc.contributor.author Anderson, Kevin
• dc.contributor.author Holmes, Avram
• dc.contributor.author Murray, John D.
• dc.contributor.author Deco, Gustavo
• dc.contributor.author van den Heuve, Martijn
• dc.contributor.author Yeo, B. T. Thomas
• dc.date.accessioned 2022-07-04T06:15:30Z
• dc.date.available 2022-07-04T06:15:30Z
• dc.date.issued 2021
• dc.description.abstract Large-scale biophysical circuit models provide mechanistic insights into the micro-scale and macro-scale properties of brain organization that shape complex patterns of spontaneous brain activity. We developed a spatially heterogeneous large-scale dynamical circuit model that allowed for variation in local synaptic properties across the human cortex. Here we show that parameterizing local circuit properties with both anatomical and functional gradients generates more realistic static and dynamic resting-state functional connectivity (FC). Furthermore, empirical and simulated FC dynamics demonstrates remarkably similar sharp transitions in FC patterns, suggesting the existence of multiple attractors. Time-varying regional fMRI amplitude may track multi-stability in FC dynamics. Causal manipulation of the large-scale circuit model suggests that sensory-motor regions are a driver of FC dynamics. Finally, the spatial distribution of sensory-motor drivers matches the principal gradient of gene expression that encompasses certain interneuron classes, suggesting that heterogeneity in excitation-inhibition balance might shape multi-stability in FC dynamics.
• dc.format.mimetype application/pdf
• dc.identifier.citation Kong X, Kong R, Orban C, Wang P, Zhang S, Anderson K, Holmes A, Murray JD, Deco G, van den Heuvel M, Yeo BTT. Sensory-motor cortices shape functional connectivity dynamics in the human brain. Nat Commun. 2021;12:6373. DOI: 10.1038/s41467-021-26704-y
• dc.identifier.doi http://doi.org/10.1038/s41467-021-26704-y
• dc.identifier.issn 2041-1723
• dc.identifier.uri http://hdl.handle.net/10230/53660
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Nature communications. 2021;12:6373.
• dc.rights © The Author(s) 2021 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Cognitive neuroscience
• dc.subject.keyword Network models
• dc.title Sensory-motor cortices shape functional connectivity dynamics in the human brain
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion