Dynamic functional connectivity reveals altered variability in functional connectivity among patients with major depressive disorder

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Demirtaş, Muratca
  • dc.contributor.author Tornador Antolin, Cristian, 1979-ca
  • dc.contributor.author Falcón, Carlesca
  • dc.contributor.author López-Solà, Marinaca
  • dc.contributor.author Hernández-Ribas, Rosaca
  • dc.contributor.author Pujol, Jesúsca
  • dc.contributor.author Menchón, José M.ca
  • dc.contributor.author Ritter, Petraca
  • dc.contributor.author Cardoner, Narcísca
  • dc.contributor.author Deco, Gustavoca
  • dc.date.accessioned 2016-07-15T09:54:05Z
  • dc.date.available 2016-07-15T09:54:05Z
  • dc.date.issued 2016ca
  • dc.description.abstract Resting-state fMRI (RS-fMRI) has become a useful tool to investigate the connectivity structure of mental health disorders. In the case of major depressive disorder (MDD), recent studies regarding the RS-fMRI have found abnormal connectivity in several regions of the brain, particularly in the default mode network (DMN). Thus, the relevance of the DMN to self-referential thoughts and ruminations has made the use of the resting-state approach particularly important for MDD. The majority of such research has relied on the grand averaged functional connectivity measures based on the temporal correlations between the BOLD time series of various brain regions. We, in our study, investigated the variations in the functional connectivity over time at global and local level using RS-fMRI BOLD time series of 27 MDD patients and 27 healthy control subjects. We found that global synchronization and temporal stability were significantly increased in the MDD patients. Furthermore, the participants with MDD showed significantly increased overall average (static) functional connectivity (sFC) but decreased variability of functional connectivity (vFC) within specific networks. Static FC increased to predominance among the regions pertaining to the default mode network (DMN), while the decreased variability of FC was observed in the connections between the DMN and the frontoparietal network.
  • dc.description.sponsorship ERC Advanced Grant: DYSTRUCTURE (to G.D.); Contract grant number: 295129; Contract grant sponsor:/nSpanish Research Project; Contract grant number: PSI2013-42091- P; Contract grant sponsor: European Union Seventh Framework Programme (FP7-ICT Human Brain Project; Contract grant number: 604102; Contract grant sponsor: del Carlos III Health Institute (to C.S.M.); Contract grant number: CP10/00604
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Demirtas M, Tornador C, López-Solà M, Hernández-Ribas R, Pujol J, Menchón JM, Ritter P, Cardoner N, Soriano-Mas C, Deco G. Dynamic functional connectivity reveals altered variability in functional connectivity among patients with major depressive disorder. Hum Brain Mapp. 2016;37(8):2918-30. DOI: 10.1002/hbm.23215ca
  • dc.identifier.doi http://dx.doi.org/10.1002/hbm.23215
  • dc.identifier.issn 1065-9471ca
  • dc.identifier.uri http://hdl.handle.net/10230/27062
  • dc.language.iso engca
  • dc.publisher Wileyca
  • dc.relation.ispartof Human Brain Mapping. 2016;37(8):2918-30
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/295129ca
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/604102
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2013-42091-P
  • dc.rights © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc./nThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.ca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
  • dc.subject.keyword Mood disorders
  • dc.subject.keyword Major depressive disorder
  • dc.subject.keyword Dynamic functional connectivity
  • dc.subject.keyword Resting state
  • dc.subject.keyword fMRI
  • dc.title Dynamic functional connectivity reveals altered variability in functional connectivity among patients with major depressive disorderca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/publishedVersionca

Col·leccions

Articles (Departament de Tecnologies de la Informació i les Comunicacions)
Articles (Hospital del Mar Research Institute)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)