Ephaptic coupling in white matter fibre bundles modulates axonal transmission delays

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• dc.contributor.author Schmidt, Helmut
• dc.contributor.author Hahn, Gerald
• dc.contributor.author Deco, Gustavo
• dc.contributor.author Knösche, Thomas R.
• dc.date.accessioned 2021-03-24T10:07:43Z
• dc.date.available 2021-03-24T10:07:43Z
• dc.date.issued 2021
• dc.description.abstract Axonal connections are widely regarded as faithful transmitters of neuronal signals with fixed delays. The reasoning behind this is that extracellular potentials caused by spikes travelling along axons are too small to have an effect on other axons. Here we devise a computational framework that allows us to study the effect of extracellular potentials generated by spike volleys in axonal fibre bundles on axonal transmission delays. We demonstrate that, although the extracellular potentials generated by single spikes are of the order of microvolts, the collective extracellular potential generated by spike volleys can reach several millivolts. As a consequence, the resulting depolarisation of the axonal membranes increases the velocity of spikes, and therefore reduces axonal delays between brain areas. Driving a neural mass model with such spike volleys, we further demonstrate that only ephaptic coupling can explain the reduction of stimulus latencies with increased stimulus intensities, as observed in many psychological experiments.
• dc.description.sponsorship HS and GH were supported by a German Research Council (DFG) grant (No. KN 588/7-1 and DE 832/1-1), awarded to GD and TRK, within priority program ‘Computational Connectomics’ (SPP 2041)]. GD was supported by the Spanish Research Project (ref. PID2019-105772GB-I00 AEI FEDER EU), funded by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI) and European Regional Development Funds (FEDER); HBP SGA3 Human Brain Project Specific Grant Agreement 3 (Grant Agreement No. 945539), funded by the EU H2020 FET Flagship program and SGR Research Support Group support (ref. 2017 SGR 1545), funded by the Catalan Agency for Management of University and Research Grants (AGAUR). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
• dc.format.mimetype application/pdf
• dc.identifier.citation Schmidt H, Hahn G, Deco G, Knösche TR. Ephaptic coupling in white matter fibre bundles modulates axonal transmission delays. PLoS Comput Biol. 2021;17(2):e1007858. DOI: 10.1371/journal.pcbi.1007858
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pcbi.1007858
• dc.identifier.issn 1553-734X
• dc.identifier.uri http://hdl.handle.net/10230/46925
• dc.language.iso eng
• dc.publisher Public Library of Science (PLoS)
• dc.relation.ispartof PLoS Comput Biol. 2021;17(2):e1007858
• dc.relation.isreferencedby https://github.com/hschmidt82/ephaptic_fibre_bundle
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-105772GB-I00
• dc.rights © 2021 Schmidt et al. This is an open access article distributed under the terms of the Creative Commons Attribution License https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Action potentials
• dc.subject.keyword Axons
• dc.subject.keyword Membrane potential
• dc.subject.keyword Biophysics
• dc.subject.keyword Sensory perception
• dc.subject.keyword Nerve fibers
• dc.subject.keyword Ranvier's nodes
• dc.subject.keyword Intracellular membranes
• dc.title Ephaptic coupling in white matter fibre bundles modulates axonal transmission delays
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion