The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness states

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• dc.contributor.author G-Guzmán, Elvira
• dc.contributor.author Sanz Perl, Yonatan
• dc.contributor.author Vohryzek, Jakub
• dc.contributor.author Escrichs, Anira
• dc.contributor.author Manasova, Dragana
• dc.contributor.author Türker, Basak
• dc.contributor.author Tagliazucchi, Enzo
• dc.contributor.author Kringelbach, Morten L.
• dc.contributor.author Sitt, Jacobo
• dc.contributor.author Deco, Gustavo
• dc.date.accessioned 2023-07-04T06:40:40Z
• dc.date.available 2023-07-04T06:40:40Z
• dc.date.issued 2023
• dc.description.abstract Life is a constant battle against equilibrium. From the cellular level to the macroscopic scale, living organisms as dissipative systems require the violation of their detailed balance, i.e. metabolic enzymatic reactions, in order to survive. We present a framework based on temporal asymmetry as a measure of non-equilibrium. By means of statistical physics, it was discovered that temporal asymmetries establish an arrow of time useful for assessing the reversibility in human brain time series. Previous studies in human and non-human primates have shown that decreased consciousness states such as sleep and anaesthesia result in brain dynamics closer to the equilibrium. Furthermore, there is growing interest in the analysis of brain symmetry based on neuroimaging recordings and since it is a non-invasive technique, it can be extended to different brain imaging modalities and applied at different temporo-spatial scales. In the present study, we provide a detailed description of our methodological approach, paying special attention to the theories that motivated this work. We test, for the first time, the reversibility analysis in human functional magnetic resonance imaging data in patients suffering from disorder of consciousness. We verify that the tendency of a decrease in the asymmetry of the brain signal together with the decrease in non-stationarity are key characteristics of impaired consciousness states. We expect that this work will open the way for assessing biomarkers for patients' improvement and classification, as well as motivating further research on the mechanistic understanding underlying states of impaired consciousness.
• dc.description.sponsorship Authors declare no competing interest. E.G.G. is supported by the Spanish Ministry of Universities for University Teacher Training Aid grant FPU 2020-02470. Y.S.P. is supported by the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant 896354. J.V. is supported by the EU H2020 FET Proactive project Neurotwin grant agreement no. 101017716. A.E. is supported by the HBP SGA3 Human Brain Project Specific Grant Agreement 3 (grant agreement no. 945539), funded by the EU H2020 FET Flagship programme. D.M. received individual funding from Ecole Doctorale Frontières de l’Innovation en Recherche et Education–Programme Bettencourt. B.T. received a PhD grant from the French Ministry of Higher Education and Ecole Normale Superieur. M.K. is supported by the Center for Music in the Brain, funded by the Danish National Research Foundation (DNRF117), and Centre for Eudaimonia and Human Flourishing at Linacre College funded by the Pettit and Carlsberg Foundations. G.D. is supported by the Spanish National Research project (AEI-PID2019-105772GB I00/AEI/10.13039/501100011033) funded by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI). J.D.S. and E.T. are funded by a grant from STIC-AmSud [project SILIDOC - 21-STIC-11], ECOS-Sud A20M02, and ECOS-Sud U20S01. J.D.S. and G.D. are supported by the ModelDXConsciousness in the framework of the FLAG-ERA JTC 2021—HBP—2021 programme.
• dc.format.mimetype application/pdf
• dc.identifier.citation G-Guzmán E, Sanz Perl Y, Vohryzek J, Escrichs A, Manasova D, Türker B, Tagliazucchi E, Kringelbach M, Sitt JD, Deco G. The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness states. Interface Focus. 2023;13(3):20220086. DOI: 10.1098/rsfs.2022.0086
• dc.identifier.doi http://dx.doi.org/10.1098/rsfs.2022.0086
• dc.identifier.issn 2042-8898
• dc.identifier.uri http://hdl.handle.net/10230/57448
• dc.language.iso eng
• dc.publisher Royal Society
• dc.relation.ispartof Interface Focus. 2023;13(3):20220086.
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/896354
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/101017716
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-105772GB-I00
• dc.rights © 2023 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword reversibility
• dc.subject.keyword disorder of consciousness
• dc.subject.keyword functional magnetic resonance imaging
• dc.subject.keyword nonequilibrium
• dc.subject.keyword temporal asymmetry
• dc.subject.keyword arrow of time
• dc.title The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness states
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion