Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm
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- dc.contributor.author Mochol, Gabrielaca
- dc.contributor.author Kiryk, Annaca
- dc.contributor.author Mochol, Gabrielaca
- dc.contributor.author Filipkowski, Robert K.ca
- dc.contributor.author Wawrzyniak, Marcinca
- dc.contributor.author Lioudyno, Victoriaca
- dc.contributor.author Knapska, Ewelinaca
- dc.contributor.author Gorkiewicz, Tomaszca
- dc.contributor.author Balcerzyk, Marcinca
- dc.contributor.author Leski, Szymonca
- dc.contributor.author Van Leuven, Fredca
- dc.contributor.author Lipp, Hans-Peterca
- dc.contributor.author Wójcik, Daniel K.ca
- dc.contributor.author Kaczmarek, Leszekca
- dc.date.accessioned 2018-07-23T13:18:07Z
- dc.date.available 2018-07-23T13:18:07Z
- dc.date.issued 2011
- dc.description.abstract In the present study, we used a new training paradigm in the intelliCage automatic behavioral assessment system to investigate cognitive functions of the transgenic mice harboring London mutation of the human amyloid precursor protein (APP.V717I). Three groups of animals: 5-, 12- and 18-24-month old were subjected to both Water Maze training and the IntelliCage-based appetitive conditioning. The spatial memory deficit was observed in all three groups of transgenic mice in both behavioral paradigms. However, the APP mice were capable to learn normally when co-housed with the wild-type (WT) littermates, in contrast to clearly impaired learning observed when the transgenic mice were housed alone. Furthermore, in the transgenic mice kept in the Intellicage alone, the cognitive deficit of the young animals was modulated by the circadian rhythm, namely was prominent only during the active phase of the day. The novel approach to study the transgenic mice cognitive abilities presented in this paper offers new insight into cognitive dysfunctions of the Alzheimers disease mouse model.en
- dc.description.sponsorship This work was supported by MemStick grant (7 Frame-work Program of EU), the NCCR “Neural Plasticity and Re-pair” and Swiss National Science Foundation.en
- dc.format.mimetype application/pdf
- dc.identifier.citation Kiryk A, Mochol G, Filipkowski RK, Wawrzyniak M, Lioudyno V, Knapska E, Gorkiewicz T, Balcerzyk M, Leski S, Van Leuven F, Lipp HP, Wójcik DK, Kaczmarek L. Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm. Curr Alzheimer Res. 2011;8(8):883-92. DOI: 10.2174/156720511798192745
- dc.identifier.doi http://dx.doi.org/10.2174/156720511798192745
- dc.identifier.issn 1567-2050
- dc.identifier.uri http://hdl.handle.net/10230/35238
- dc.language.iso eng
- dc.publisher Bentham Science Publishersca
- dc.relation.ispartof Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm. Current Alzheimer Research. 2011;8(8):883-92.
- dc.rights © Bentham Science Publishers. Article published in Kiryk A, Mochol G, Filipkowski RK, Wawrzyniak M, Lioudyno V, Knapska E, Gorkiewicz T, Balcerzyk M, Leski S, Van Leuven F, Lipp HP, Wójcik DK, Kaczmarek L. Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm. Current Alzheimer Research. 2011;8(8):883-92.. The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/89141/article
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Circadian rhythmen
- dc.subject.keyword Group learningen
- dc.subject.keyword Individual learningen
- dc.subject.keyword IntelliCageen
- dc.subject.keyword Social behavioren
- dc.subject.keyword Amyloid precursor proteinen
- dc.subject.keyword IntelliCage systemen
- dc.subject.keyword Ageingen
- dc.subject.keyword Sensorimotoren
- dc.title Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythmca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion