Clinical relevance of different loads of perivascular spaces according to their localization in patients with a recent small subcortical infarct
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Sozzi, Caterina
- dc.contributor.author Brenlla, Carla
- dc.contributor.author Bartolomé, Inés
- dc.contributor.author Girona, Andrés
- dc.contributor.author Muñoz-Moreno, Emma
- dc.contributor.author Laredo, Carlos
- dc.contributor.author Rodríguez-Vázquez, Alejandro
- dc.contributor.author Doncel-Moriano, Antonio
- dc.contributor.author Rudilosso, Salvatore
- dc.contributor.author Chamorro, Ángel
- dc.date.accessioned 2025-11-24T07:03:58Z
- dc.date.available 2025-11-24T07:03:58Z
- dc.date.issued 2024
- dc.description.abstract Background and Purpose: Perivascular spaces (PVS) are usually enlarged in small vessel disease (SVD). However, the significance of PVS patterns in different locations is uncertain. Hence, we analyzed the distribution of PVS in patients with a recent small subcortical infarct (RSSI) and their correlation with clinical and imaging factors. Materials and Methods: In a cohort of 71 patients with an RSSI with complete clinical data, including the Pittsburgh Sleep Quality Index (PSQI), we segmented PVS in white matter (WM-PVS), basal ganglia (BG-PVS), and brainstems (BS-PVS) on 3T-MRI T2-weighted sequences, obtaining fractional volumes (%), and calculated the WM/BG-PVS ratio. We analyzed the Pearson’s correlation coefficients between PVS regional loads. We used normalized PVS measures to assess the associations with clinical and MRI-SVD features (white matter hyperintensities (WMHs), number of lacunes, and microbleeds) in univariable and multivariable linear regressions adjusted for age, sex, and hypertension. Results: In our cohort (mean age 70 years; 27% female), the Pearson’s correlation coefficients between WM-PVS/BG-PVS, WM-PVS/BS-PVS, and BG-PVS/BS-PVS were 0.67, 0.61, and 0.59 (all p < 0.001). In the adjusted models, BG-PVS were associated with lacunes (p = 0.034), WMHs (p = 0.006), and microbleeds (p = 0.017); WM-PVS with lacunes (p = 0.003); while BS-PVS showed no associations. The WM/BG-PVS ratio was associated with lacunes (p = 0.018) and the PSQI (p = 0.046). Conclusions: PVS burdens in different regions are highly correlated in patients with RSSI but with different SVD patterns. Sleep quality impairment might affect waste removal mechanisms differently in the WM and BG regions.en
- dc.format.mimetype application/pdf
- dc.identifier.citation Sozzi C, Brenlla C, Bartolomé I, Girona A, Muñoz-Moreno E, Laredo C, et al. Clinical relevance of different loads of perivascular spaces according to their localization in patients with a recent small subcortical infarct. J Cardiovasc Dev Dis. 2024;11(11):345. DOI: 10.3390/jcdd11110345
- dc.identifier.doi http://dx.doi.org/10.3390/jcdd11110345
- dc.identifier.issn 2308-3425
- dc.identifier.uri http://hdl.handle.net/10230/71974
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Journal of Cardiovascular Development and Disease. 2024;11(11):345
- dc.rights © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Cerebral small vessel diseaseen
- dc.subject.keyword Lacunar strokeen
- dc.subject.keyword Perivascular spacesen
- dc.subject.keyword Sleepen
- dc.title Clinical relevance of different loads of perivascular spaces according to their localization in patients with a recent small subcortical infarcten
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion