Re-awakening the brain: forcing transitions in disorders of consciousness by external in silico perturbation

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• dc.contributor.author Dagnino, Paulina Clara
• dc.contributor.author Escrichs, Anira
• dc.contributor.author López-González, Ane
• dc.contributor.author Gosseries, Olivia
• dc.contributor.author Annen, Jitka
• dc.contributor.author Sanz Perl, Yonatan
• dc.contributor.author Kringelbach, Morten L.
• dc.contributor.author Laureys, Steven
• dc.contributor.author Deco, Gustavo
• dc.date.accessioned 2025-03-27T08:16:08Z
• dc.date.available 2025-03-27T08:16:08Z
• dc.date.issued 2024
• dc.description.abstract A fundamental challenge in neuroscience is accurately defining brain states and predicting how and where to perturb the brain to force a transition. Here, we investigated resting-state fMRI data of patients suffering from disorders of consciousness (DoC) after coma (minimally conscious and unresponsive wakefulness states) and healthy controls. We applied model-free and model-based approaches to help elucidate the underlying brain mechanisms of patients with DoC. The model-free approach allowed us to characterize brain states in DoC and healthy controls as a probabilistic metastable substate (PMS) space. The PMS of each group was defined by a repertoire of unique patterns (i.e., metastable substates) with different probabilities of occurrence. In the model-based approach, we adjusted the PMS of each DoC group to a causal whole-brain model. This allowed us to explore optimal strategies for promoting transitions by applying off-line in silico probing. Furthermore, this approach enabled us to evaluate the impact of local perturbations in terms of their global effects and sensitivity to stimulation, which is a model-based biomarker providing a deeper understanding of the mechanisms underlying DoC. Our results show that transitions were obtained in a synchronous protocol, in which the somatomotor network, thalamus, precuneus and insula were the most sensitive areas to perturbation. This motivates further work to continue understanding brain function and treatments of disorders of consciousness.
• dc.format.mimetype application/pdf
• dc.identifier.citation Dagnino PC, Escrichs A, López-González A, Gosseries O, Annen J, Sanz Perl, et al. Re-awakening the brain: forcing transitions in disorders of consciousness by external in silico perturbation. PLoS Comput Biol. 2024 May 3;20(5):e1011350. DOI: 10.1371/journal.pcbi.1011350
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pcbi.1011350
• dc.identifier.issn 1553-7358
• dc.identifier.uri http://hdl.handle.net/10230/70030
• dc.language.iso eng
• dc.publisher Public Library of Science (PLoS)
• dc.relation.ispartof PLoS Computational Biology. 2024 May 3;20(5):e1011350
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/896354
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
• dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101071900
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2022-136216NB-I00
• dc.rights Copyright: © 2024 Dagnino et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.other Cervell
• dc.subject.other Consciència (Psicologia)
• dc.subject.other Estats alterats de consciència
• dc.title Re-awakening the brain: forcing transitions in disorders of consciousness by external in silico perturbation
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion