MDRD o CKD-EPI en la estimación del filtrado glomerulardel donante renal vivo

Burballa Tàrrega, Carla, 1988-; Crespo Barrio, Marta; Redondo Pachón, María Dolores; Pérez-Sáez, María José; Mir Fontana, M. Luisa; Arias Cabrales, Carlos Enrique; Frances, Albert; Fumadó Ciutat, Lluis; Cecchini Rosell, Lluís; Pascual Santos, Julio

doi:http://dx.doi.org/10.1016/j.nefro.2017.02.007

MDRD o CKD-EPI en la estimación del filtrado glomerulardel donante renal vivo

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Burballa C, Crespo M, Redondo-Pachón D, Pérez-Sáez MJ, Mir M, Arias-Cabrales C. et al. MDRD o CKD-EPI en la estimación del filtrado glomerular del donante renal vivo. Nefrologia. 2018 Mar-Apr;38(2):207-212. DOI: 10.1016/j.nefro.2017.02.007

Abstract

INTRODUCTION: The evaluation of the measured Glomerular Filtration Rate (mGFR) or estimated Glomerular Filtration Rate (eGFR) is key in the proper assessment of the renal function of potential kidney donors. We aim to study the correlation between glomerular filtration rate estimation equations and the measured methods for determining renal function. MATERIAL AND METHODS: We analysed the relationship between baseline GFR values measured by Tc-99m-DTPA (diethylene-triamine-pentaacetate) and those estimated by the four-variable Modification of Diet in Renal Disease (MDRD4) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations in a series of living donors at our institution. RESULTS: We included 64 donors (70.6% females; mean age 48.3±11 years). Baseline creatinine was 0.8±0.1 mg/dl and it was 1.1±0.2 mg/dl one year after donation. The equations underestimated GFR when measured by Tc99m-DTPA (MDRD4-9.4 ± 25ml/min, P<.05, and CKD-EPI-4.4 ± 21ml/min). The correlation between estimation equations and the measured method was superior for CKD-EPI (r=.41; P<.004) than for MDRD4 (r=.27; P<.05). eGFR decreased to 59.6±11 (MDRD4) and 66.2±14ml/min (CKD-EPI) one year after donation. This means a mean eGFR reduction of 28.2±16.7 ml/min (MDRD4) and 27.31±14.4 ml/min (CKD-EPI) at one year. CONCLUSIONS: In our experience, CKD-EPI is the equation that better correlates with mGFR-Tc99m-DTPA when assessing renal function for donor screening purposes.