MDRD o CKD-EPI en la estimación del filtrado glomerulardel donante renal vivo

Burballa Tàrrega, Carla, 1988-; Crespo Barrio, Marta; Redondo Pachón, María Dolores; Pérez-Sáez, María José; Mir Fontana, M. Luisa; Arias Cabrales, Carlos Enrique; Frances, Albert; Fumadó Ciutat, Lluis; Cecchini Rosell, Lluís; Pascual Santos, Julio

MDRD o CKD-EPI en la estimación del filtrado glomerulardel donante renal vivo

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dc.contributor.author Burballa Tàrrega, Carla, 1988-ca
dc.contributor.author Crespo Barrio, Martaca
dc.contributor.author Redondo Pachón, María Doloresca
dc.contributor.author Pérez-Sáez, María Joséca
dc.contributor.author Mir Fontana, M. Luisaca
dc.contributor.author Arias Cabrales, Carlos Enriqueca
dc.contributor.author Frances, Albertca
dc.contributor.author Fumadó Ciutat, Lluisca
dc.contributor.author Cecchini Rosell, Lluísca
dc.contributor.author Pascual Santos, Julioca
dc.date.accessioned 2018-03-12T08:35:16Z
dc.date.available 2018-03-12T08:35:16Z
dc.date.issued 2018
dc.description.abstract INTRODUCTION: The evaluation of the measured Glomerular Filtration Rate (mGFR) or estimated Glomerular Filtration Rate (eGFR) is key in the proper assessment of the renal function of potential kidney donors. We aim to study the correlation between glomerular filtration rate estimation equations and the measured methods for determining renal function. MATERIAL AND METHODS: We analysed the relationship between baseline GFR values measured by Tc-99m-DTPA (diethylene-triamine-pentaacetate) and those estimated by the four-variable Modification of Diet in Renal Disease (MDRD4) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations in a series of living donors at our institution. RESULTS: We included 64 donors (70.6% females; mean age 48.3±11 years). Baseline creatinine was 0.8±0.1 mg/dl and it was 1.1±0.2 mg/dl one year after donation. The equations underestimated GFR when measured by Tc99m-DTPA (MDRD4-9.4 ± 25ml/min, P<.05, and CKD-EPI-4.4 ± 21ml/min). The correlation between estimation equations and the measured method was superior for CKD-EPI (r=.41; P<.004) than for MDRD4 (r=.27; P<.05). eGFR decreased to 59.6±11 (MDRD4) and 66.2±14ml/min (CKD-EPI) one year after donation. This means a mean eGFR reduction of 28.2±16.7 ml/min (MDRD4) and 27.31±14.4 ml/min (CKD-EPI) at one year. CONCLUSIONS: In our experience, CKD-EPI is the equation that better correlates with mGFR-Tc99m-DTPA when assessing renal function for donor screening purposes.
dc.format.mimetype application/pdf
dc.identifier.citation Burballa C, Crespo M, Redondo-Pachón D, Pérez-Sáez MJ, Mir M, Arias-Cabrales C. et al. MDRD o CKD-EPI en la estimación del filtrado glomerular del donante renal vivo. Nefrologia. 2018 Mar-Apr;38(2):207-212. DOI: 10.1016/j.nefro.2017.02.007
dc.identifier.doi http://dx.doi.org/10.1016/j.nefro.2017.02.007
dc.identifier.issn 0211-6995
dc.identifier.uri http://hdl.handle.net/10230/34079
dc.language.iso spa
dc.publisher Elsevierca
dc.relation.ispartof Nefrologia. 2018 Mar-Apr;38(2):207-12
dc.rights © 2017 Sociedad Española de Nefrología. Publicado por Elsevier España, S.L.U. Este es un artículo Open Access bajo la licencia CC BY-NC-ND (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keyword CKD-EP
dc.subject.keyword Donante renal vivo
dc.subject.keyword Filtrado glomerular
dc.subject.keyword Glomerular filtration rate
dc.subject.keyword Living kidney donor
dc.subject.keyword MDRD4
dc.subject.keyword Tc(99)m-DTPA
dc.subject.other Donants d'òrgans
dc.subject.other Ronyons -- Trasplantació
dc.title MDRD o CKD-EPI en la estimación del filtrado glomerulardel donante renal vivoca
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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