Structure-function discrepancy: inhomogeneity and/ndelays in synchronized neural networks
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- dc.contributor.author Ton, Robertca
- dc.contributor.author Deco, Gustavoca
- dc.contributor.author Daffertshofer, Andreasca
- dc.date.accessioned 2015-02-02T09:29:46Z
- dc.date.available 2015-02-02T09:29:46Z
- dc.date.issued 2014ca
- dc.description.abstract The discrepancy between structural and functional connectivity in neural systems forms the challenge in understanding/ngeneral brain functioning. To pinpoint a mapping between structure and function, we investigated the effects of/n(in)homogeneity in coupling structure and delays on synchronization behavior in networks of oscillatory neural masses by/nderiving the phase dynamics of these generic networks. For homogeneous delays, the structural coupling matrix is largely/npreserved in the coupling between phases, resulting in clustered stationary phase distributions. Accordingly, we found only/na small number of synchronized groups in the network. Distributed delays, by contrast, introduce inhomogeneity in the/nphase coupling so that clustered stationary phase distributions no longer exist. The effect of distributed delays mimicked/nthat of structural inhomogeneity. Hence, we argue that phase (de-)synchronization patterns caused by inhomogeneous/ncoupling cannot be distinguished from those caused by distributed delays, at least not by the naked eye. The here-derived/nanalytical expression for the effective coupling between phases as a function of structural coupling constitutes a direct/nrelationship between structural and functional connectivity. Structural connectivity constrains synchronizability that may be/nmodified by the delay distribution. This explains why structural and functional connectivity bear much resemblance albeit/nnot a one-to-one correspondence. We illustrate this in the context of resting-state activity, using the anatomical/nconnectivity structure reported by Hagmann and others.en
- dc.description.sponsorship This work was funded by ERC Advanced Grant: DYSTRUCTURE (n. 295129), by the Spanish Research Project SAF2010-16085 and by the CONSOLIDER-/nINGENIO 2010 Program CSD2007-00012, and the FP7-ICT BrainScale
- dc.format.extent 15 p.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Ton R, Deco G, Daffertshofer A. Structure-function discrepancy: inhomogeneity and delays in synchronized neural networks. PLoS Comput Biol. 2014;10(7):e1003736. DOI: 10.1371/journal.pcbi.1003736ca
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pcbi.1003736
- dc.identifier.issn 1553-734Xca
- dc.identifier.uri http://hdl.handle.net/10230/23091
- dc.language.iso engca
- dc.publisher Public Library of Science (PLoS)ca
- dc.relation.ispartof PLoS Computational Biology. 2014;10(7):e1003736
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/295129ca
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/269921
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2010-16085
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/CSD2007-00012
- dc.rights © 2014 Ton et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.title Structure-function discrepancy: inhomogeneity and/ndelays in synchronized neural networksca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca