The changing chromatome as a driver of disease: a panoramic view from different methodologies
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- dc.contributor.author Espejo, Isabel
- dc.contributor.author Di Croce, Luciano
- dc.contributor.author Aranda Aragón, Sergio
- dc.date.accessioned 2020-12-22T11:38:40Z
- dc.date.available 2020-12-22T11:38:40Z
- dc.date.issued 2020
- dc.description.abstract Chromatin-bound proteins underlie several fundamental cellular functions, such as control of gene expression and the faithful transmission of genetic and epigenetic information. Components of the chromatin proteome (the "chromatome") are essential in human life, and mutations in chromatin-bound proteins are frequently drivers of human diseases, such as cancer. Proteomic characterization of chromatin and de novo identification of chromatin interactors could, thus, reveal important and perhaps unexpected players implicated in human physiology and disease. Recently, intensive research efforts have focused on developing strategies to characterize the chromatome composition. In this review, we provide an overview of the dynamic composition of the chromatome, highlight the importance of its alterations as a driving force in human disease (and particularly in cancer), and discuss the different approaches to systematically characterize the chromatin-bound proteome in a global manner.
- dc.description.sponsorship I.E. is supported by La CaixaINPhINIT program. L.D.C is supported by grants from the Spanish of Economy, Industry and Competitiveness (MEIC) (BFU2016‐75008‐P), “FundaciónVencer El Cancer” (VEC), the European Regional Development Fund (FEDER), Fundació “La Marató de TV3”, and from AGAUR. S.A. is funded by Ramón y Cajal Program MICIU‐FSE (RYC2018‐025002‐I) and ISCIII‐FEDER (PI19/01814)
- dc.format.mimetype application/pdf
- dc.identifier.citation Espejo I, Di Croce L, Aranda S. The changing chromatome as a driver of disease: a panoramic view from different methodologies. Bioessays. 2020 Dec; 42(12):e 2000203. DOI: 10.1002/bies.202000203
- dc.identifier.doi http://dx.doi.org/10.1002/bies.202000203
- dc.identifier.issn 0265-9247
- dc.identifier.uri http://hdl.handle.net/10230/46111
- dc.language.iso eng
- dc.publisher Wiley-VCH Verlag
- dc.relation.ispartof Bioessays. 2020 Dec;42(12):e2000203
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2016‐75008‐P
- dc.rights © 2020 Wiley Periodicals LLC. The changing chromatome as a driver of disease: a panoramic view from different methodologies. Isabel Espejo, Luciano Di Croce, Sergi Aranda. Bioessays. Volum 42, número 12
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.other Cromatina
- dc.subject.other Càncer
- dc.subject.other Proteòmica
- dc.title The changing chromatome as a driver of disease: a panoramic view from different methodologies
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion