Complex congenital heart disease associated with disordered myocardial architecture in a midtrimester human fetus
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- dc.contributor.author Garcia Canadilla, Patricia
- dc.contributor.author Dejea i Velardo, Hèctor
- dc.contributor.author Bonnin, Anne
- dc.contributor.author Balicevic, Vedrana
- dc.contributor.author Loncaric, Sven
- dc.contributor.author Zhang, Chong
- dc.contributor.author Butakoff, Constantine
- dc.contributor.author Aguado-Sierra, Jazmin
- dc.contributor.author Vázquez, Mariano
- dc.contributor.author Jackson, Laurence H.
- dc.contributor.author Stuckey, Daniel J.
- dc.contributor.author Rau, Cristoph
- dc.contributor.author Stampanoni, Marco
- dc.contributor.author Bijnens, Bart
- dc.contributor.author Cook, Andrew C.
- dc.date.accessioned 2019-03-27T09:24:36Z
- dc.date.issued 2018
- dc.description.abstract In the era of increasingly successful corrective interventions in patients with congenital heart disease (CHD), global and regional myocardial remodeling are emerging as important sources of long-term morbidity/mortality. Changes in organization of the myocardium in CHD, and in its mechanical properties, conduction, and blood supply, result in altered myocardial function both before and after surgery. To gain a better understanding and develop appropriate and individualized treatment strategies, the microscopic organization of cardiomyocytes, and their integration at a macroscopic level, needs to be completely understood. The aim of this study is to describe, for the first time, in 3 dimensions and nondestructively the detailed remodeling of cardiac microstructure present in a human fetal heart with complex CHD.
- dc.description.sponsorship This study was partially supported by the Spanish Ministry of Economy and Competitiveness (grant TIN2014-52923-R and the Maria de Maeztu Units of Excellence Programme - MDM- 2015-0502) and FEDER. CB is supported by Fundació La Marató de TV3 (Spain), grant Nº: 20154031. JAS is supported by the Center of Excellence CompBioMed funded under H2020-EU.1.4.1.3. under grant agreement Nº 675451. DJS is supported by the British Heart Foundation under the grant Nº FS/15/33/31608.
- dc.format.mimetype application/pdf
- dc.identifier.citation Garcia-Canadilla P, Dejea H, Bonnin A, Balicevic V, Loncaric S, Zhang C, Butakoff C, Aguado-Sierra J, Vázquez M, Jackson LH, Stuckey DJ, Rau C, Stampanoni M, Bijnens B, Cook AC. Complex congenital heart disease associated with disordered myocardial architecture in a midtrimester human fetus. Circ Cardiovasc Imaging. 2018 Oct 15;11(10):e007753. DOI: 10.1161/CIRCIMAGING.118.007753
- dc.identifier.doi http://dx.doi.org/10.1161/CIRCIMAGING.118.007753
- dc.identifier.issn 1941-9651
- dc.identifier.uri http://hdl.handle.net/10230/36985
- dc.language.iso eng
- dc.publisher American Hearth Association
- dc.relation.ispartof Circulation: Cardiovascular Imaging. 2018 Oct 15;11(10):e007753.
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TIN2014-52923-R
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/675451
- dc.rights © American Hearth Association http://dx.doi.org/10.1161/CIRCIMAGING.118.007753
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Isomerism
- dc.subject.keyword Synchrotrons
- dc.subject.keyword Humans
- dc.subject.keyword Myocardium
- dc.subject.keyword Fetal heart
- dc.subject.keyword X-ray microtomography
- dc.title Complex congenital heart disease associated with disordered myocardial architecture in a midtrimester human fetus
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion