Models of metaplasticity: a review of concepts
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Yger, Pierre
- dc.contributor.author Gilson, Matthieu
- dc.date.accessioned 2025-02-03T07:49:27Z
- dc.date.available 2025-02-03T07:49:27Z
- dc.date.issued 2015
- dc.description.abstract Part of hippocampal and cortical plasticity is characterized by synaptic modifications that depend on the joint activity of the pre- and post-synaptic neurons. To which extent those changes are determined by the exact timing and the average firing rates is still a matter of debate; this may vary from brain area to brain area, as well as across neuron types. However, it has been robustly observed both in vitro and in vivo that plasticity itself slowly adapts as a function of the dynamical context, a phenomena commonly referred to as metaplasticity. An alternative concept considers the regulation of groups of synapses with an objective at the neuronal level, for example, maintaining a given average firing rate. In that case, the change in the strength of a particular synapse of the group (e.g., due to Hebbian learning) affects others' strengths, which has been coined as heterosynaptic plasticity. Classically, Hebbian synaptic plasticity is paired in neuron network models with such mechanisms in order to stabilize the activity and/or the weight structure. Here, we present an oriented review that brings together various concepts from heterosynaptic plasticity to metaplasticity, and show how they interact with Hebbian-type learning. We focus on approaches that are nowadays used to incorporate those mechanisms to state-of-the-art models of spiking plasticity inspired by experimental observations in the hippocampus and cortex. Making the point that metaplasticity is an ubiquitous mechanism acting on top of classical Hebbian learning and promoting the stability of neural function over multiple timescales, we stress the need for incorporating it as a key element in the framework of plasticity models. Bridging theoretical and experimental results suggests a more functional role for metaplasticity mechanisms than simply stabilizing neural activity.en
- dc.format.mimetype application/pdf
- dc.identifier.citation Yger P, Gilson M. Models of metaplasticity: a review of concepts. Front Comput Neurosci. 2015 Nov 10;9:20146. DOI: 10.3389/fncom.2015.00138
- dc.identifier.doi http://dx.doi.org/10.3389/fncom.2015.00138
- dc.identifier.issn 1662-5188
- dc.identifier.uri http://hdl.handle.net/10230/69444
- dc.language.iso eng
- dc.publisher Frontiers
- dc.relation.ispartof Frontiers in Computational Neuroscience. 2015 Nov 10;9:20146
- dc.rights © 2015 Yger and Gilson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Synaptic plasticityen
- dc.subject.keyword Metaplasticityen
- dc.subject.keyword Hebbian learningen
- dc.subject.keyword Homeostasisen
- dc.subject.keyword STDPen
- dc.title Models of metaplasticity: a review of conceptsen
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion