Subcortical-cortical dynamical states of the human brain and their breakdown in stroke

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Favaretto, Chiara
• dc.contributor.author Allegra, Michele
• dc.contributor.author Deco, Gustavo
• dc.contributor.author Metcalf, Nicholas V.
• dc.contributor.author Griffis, Joseph C.
• dc.contributor.author Shulman, Gordon L.
• dc.contributor.author Brovelli, Andrea
• dc.contributor.author Corbetta, Maurizio
• dc.date.accessioned 2023-03-08T07:25:21Z
• dc.date.available 2023-03-08T07:25:21Z
• dc.date.issued 2022
• dc.description.abstract The mechanisms controlling dynamical patterns in spontaneous brain activity are poorly understood. Here, we provide evidence that cortical dynamics in the ultra-slow frequency range (<0.01–0.1 Hz) requires intact cortical-subcortical communication. Using functional magnetic resonance imaging (fMRI) at rest, we identify Dynamic Functional States (DFSs), transient but recurrent clusters of cortical and subcortical regions synchronizing at ultra-slow frequencies. We observe that shifts in cortical clusters are temporally coincident with shifts in subcortical clusters, with cortical regions flexibly synchronizing with either limbic regions (hippocampus/amygdala), or subcortical nuclei (thalamus/basal ganglia). Focal lesions induced by stroke, especially those damaging white matter connections between basal ganglia/thalamus and cortex, provoke anomalies in the fraction times, dwell times, and transitions between DFSs, causing a bias toward abnormal network integration. Dynamical anomalies observed 2 weeks after stroke recover in time and contribute to explaining neurological impairment and long-term outcome.
• dc.description.sponsorship C.F., M.A., A.B., and M.C. are supported by FLAG-ERA JTC 2017 (grant ANR-17-HBPR-0001). C.F. and M.C. are supported by Fondazione Cassa di Risparmio di Padova e Rovigo (CARIPARO) - Ricerca Scientifica di Eccellenza 2018 – (Grant Agreement number 55403). A.B. has received funding from the European Union’s Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 945539 (Human Brain Project SGA3). M.C. is also supported by MIUR - Departments of Excellence Italian Ministry of Research (MART_ECCELLENZA18_01); Ministry of Health Italy Brain connectivity measured with high-density electroencephalography: a novel neurodiagnostic tool for stroke - NEUROCONN (RF-2008 −12366899); H2020 European School of Network Neuroscience - euSNN, H2020-SC5-2019-2 (Grant Agreement number 869505).
• dc.format.mimetype application/pdf
• dc.identifier.citation Favaretto C, Allegra M, Deco G, Metcalf NV, Griffis JC, Shulman GL, Brovelli A, Corbetta M. Subcortical-cortical dynamical states of the human brain and their breakdown in stroke. Nat Commun. 2022;13:5069. DOI: 10.1038/s41467-022-32304-1
• dc.identifier.doi http://dx.doi.org/10.1038/s41467-022-32304-1
• dc.identifier.issn 2041-1723
• dc.identifier.uri http://hdl.handle.net/10230/56104
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Nature Communications. 2022;13:5069.
• dc.relation.isreferencedby https://github.com/CorbettaLab/Favaretto2022NatComm
• dc.relation.isreferencedby https://cnda.wustl.edu/data/projects/CCIR_00299
• dc.relation.isreferencedby https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-022-32304-1/MediaObjects/41467_2022_32304_MOESM1_ESM.pdf
• dc.relation.isreferencedby https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-022-32304-1/MediaObjects/41467_2022_32304_MOESM2_ESM.pdf
• dc.relation.isreferencedby https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-022-32304-1/MediaObjects/41467_2022_32304_MOESM3_ESM.pdf
• dc.relation.isreferencedby https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-022-32304-1/MediaObjects/41467_2022_32304_MOESM4_ESM.zip
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/869505
• dc.rights © Springer Nature Publishing AG https://doi.org/10.1038/s41467-022-32304-1 Creative Commons Attribution Non-Commercial Share Alike
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Neural circuits
• dc.subject.keyword Stroke
• dc.title Subcortical-cortical dynamical states of the human brain and their breakdown in stroke
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion