Bilingualism's effects on resting-state functional connectivity in mild cognitive impairment

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• dc.contributor.author Marin-Marin, Lidon
• dc.contributor.author Palomar García, María Ángeles
• dc.contributor.author Miró Padilla, Anna
• dc.contributor.author Adrián Ventura, Jesús
• dc.contributor.author Aguirre, Naiara
• dc.contributor.author Villar Rodríguez, Esteban
• dc.contributor.author Costumero, Víctor
• dc.date.accessioned 2021-04-09T06:16:21Z
• dc.date.issued 2021
• dc.description.abstract Background: Bilingualism is considered a cognitive reserve (CR) factor, due to the delay in the onset of dementia in bilinguals compared with monolinguals. Two neural mechanisms have been suggested to underlie CR: neural reserve and neural compensation. However, it is still unclear how bilingualism contributes to these mechanisms.Methods: In this study, we used cognitive tests, functional connectivity (FC), regional homogeneity, and fractional amplitude of low-frequency fluctuations (fALFF) measures to study resting-state brain patterns in a sample of bilingual and monolingual subjects with mild cognitive impairment. Results: We found no significant differences between the groups in age, sex, education, or cognitive level, but bilinguals showed higher FC than monolinguals between the posterior part of the superior temporal gyrus and the precuneus, positively correlated with Mini-Mental State Examination scores, and higher fALFF in the thalamus bilaterally. Conclusions: Our results suggest that bilingualism may act as a CR factor that protects against dementia through neural compensation.
• dc.description.sponsorship This work was supported by the project (201410-30-31) provided by Fundació Marató TV3. L. M-M., N. A. and J. A-V. were supported by an FPU grant from the Spanish Ministry of Education, Culture and Sports, and E. V-R., by an FPU grant from the Ministry of Science, Innovation and Universities. M-Á. P-G. and A. M-P. were supported by a postdoctoral graduate program grant (University Jaume I) and V.C. was supported by a Juan de la Cierva post-doctoral graduate program grant from the Spanish Ministry of Economy, Industry and Competitiveness (IJCI-2016-29247).
• dc.format.mimetype application/pdf
• dc.identifier.citation Marin-Marin L, Palomar-García MA, Miró-Padilla A, Adrián-Ventura J, Aguirre N, Villar-Rodríguez E, Costumero V. Bilingualism's effects on resting-state functional connectivity in mild cognitive impairment. Brain Connect. 2021 Feb 12;11(1):30-7. DOI: 10.1089/brain.2020.0877
• dc.identifier.doi http://dx.doi.org/10.1089/brain.2020.0877
• dc.identifier.issn 2158-0014
• dc.identifier.uri http://hdl.handle.net/10230/47062
• dc.language.iso eng
• dc.publisher Mary Ann Liebert, Inc
• dc.relation.ispartof Brain Connectivity. 2021 Feb 12;11(1):30-7
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/IJCI-2016-29247
• dc.rights Final publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/10.1089/brain.2020.0877
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Bilingualism
• dc.subject.keyword Mild cognitive impairment
• dc.subject.keyword Resting-state
• dc.subject.keyword Functional connectivity
• dc.subject.keyword Cognitive reserve
• dc.subject.keyword fMRI
• dc.title Bilingualism's effects on resting-state functional connectivity in mild cognitive impairment
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion