Basal ventricular septal hypertrophy in systemic hypertension
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Loncaric, Filip
- dc.contributor.author Nunno, Loredana
- dc.contributor.author Mimbrero, Maria
- dc.contributor.author Marciniak, Maciej
- dc.contributor.author Fernandes, João, 1964-
- dc.contributor.author Tirapu, Laia
- dc.contributor.author Fabijanovic, Dora
- dc.contributor.author Sanchis, Laura
- dc.contributor.author Doltra, Adelina
- dc.contributor.author Cikes, Maja
- dc.contributor.author Lamata, Pablo
- dc.contributor.author Bijnens, Bart
- dc.contributor.author Sitges, Marta
- dc.date.accessioned 2021-05-18T07:39:51Z
- dc.date.available 2021-05-18T07:39:51Z
- dc.date.issued 2020
- dc.description.abstract Basal septal hypertrophy (BSH) is commonly seen in patients with systemic hypertension and has been associated with increased afterload. The impact of localized hypertrophy on left ventricular (LV) and left atrial (LA) function is still unclear. Our aim is to investigate if BSH is a marker of a more pronounced impact of hypertension on cardiac function in the early stages of hypertensive heart disease. An echocardiogram was performed in 163 well-controlled hypertensive patients and 22 healthy individuals. BSH was defined by a basal-to-mid septal thickness ratio ≥1.4. LV dimensions and mass were evaluated. LV global and regional deformation was assessed by 2-dimensional (2D) speckle tracking echocardiography, and LV diastolic function by 2D and Doppler imaging. LA function was evaluated with phasic volume indices calculated from 2D and 3-dimensional volumes, as well as speckle tracking echocardiography. The population was 54% men, mean age 57 (53 to 60) years. BSH was seen in 20% (n = 32) of the hypertensive cohort. Patients with BSH showed decreased regional LV systolic deformation, impaired LV relaxation with a higher proportion of indeterminate LV diastolic function, and LA functional impairment defined by a reduction of reservoir strain and a change in LA functional dynamics. In conclusion, in well-controlled hypertension impairment of LV and LA function is present in patients with early LV remodeling and localized hypertrophy. BSH might be useful as an early marker of the burden of hypertensive heart disease.en
- dc.description.sponsorship This work was supported by Horizon 2020 European Commission Project H2020-MSCA-ITN- 2016 (764738), Grant from Fundacio La Marato de TV3 (040310, Exp 2015.40.30), and from Fondo de Investigaciones Sanitarias - Instituto de Salud Carlos III (PI17/ 01131).
- dc.format.mimetype application/pdf
- dc.identifier.citation Loncaric F, Nunno L, Mimbrero M, Marciniak M, Fernandes JF, Tirapu L, Fabijanovic D, Sanchis L, Doltra A, Cikes M, Lamata P, Bijnens B, Sitges M. Basal ventricular septal hypertrophy in systemic hypertension. Am J Cardiol. 2020 Feb 7;125(9):1339-46. DOI: 10.1016/j.amjcard.2020.01.045
- dc.identifier.doi http://dx.doi.org/10.1016/j.amjcard.2020.01.045
- dc.identifier.issn 0002-9149
- dc.identifier.uri http://hdl.handle.net/10230/47577
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof The American journal of cardiology. 2020 Feb 7;125(9):1339-46
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/764738
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.amjcard.2020.01.045
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.title Basal ventricular septal hypertrophy in systemic hypertensionen
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion