In silico pace-mapping: prediction of left vs. right outflow tract origin in idiopathic ventricular arrhythmias with patient-specific electrophysiological simulations
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- dc.contributor.author Doste Beltrán, Rubén
- dc.contributor.author Sebastián Aguilar, Rafael, 1978-
- dc.contributor.author Gomez, Juan Francisco
- dc.contributor.author Soto-Iglesias, David
- dc.contributor.author Alcaine, Alejandro
- dc.contributor.author Mont, Lluís
- dc.contributor.author Berruezo Sánchez, Antonio
- dc.contributor.author Penela, Diego
- dc.contributor.author Camara, Oscar
- dc.date.accessioned 2020-12-17T10:44:22Z
- dc.date.issued 2020
- dc.description.abstract Aims A pre-operative non-invasive identification of the site of origin (SOO) of outflow tract ventricular arrhythmias (OTVAs) is important to properly plan radiofrequency ablation procedures. Although some algorithms based on electrocardiograms (ECGs) have been developed to predict left vs. right ventricular origins, their accuracy is still limited, especially in complex anatomies. The aim of this work is to use patient-specific electrophysiological simulations of the heart to predict the SOO in OTVA patients. Methods and results An in silico pace-mapping procedure was designed and used on 11 heart geometries, generating for each case simulated ECGs from 12 clinically plausible SOO. Subsequently, the simulated ECGs were compared with patient ECG data obtained during the clinical tachycardia using the 12-lead correlation coefficient (12-lead ρ). Left ventricle (LV) vs. right ventricle (RV) SOO was estimated by computing the LV/RV ratio for each patient, obtained by dividing the average 12-lead ρ value of the LV- and RV-SOO simulated ECGs, respectively. Simulated ECGs that had virtual sites close to the ablation points that stopped the arrhythmia presented higher correlation coefficients. The LV/RV ratio correctly predicted LV vs. RV SOO in 10/11 cases; 1.07 vs. 0.93 P < 0.05 for 12-lead ρ. Conclusion The obtained results demonstrate the potential of the developed in silico pace-mapping technique to complement standard ECG for the pre-operative planning of complex ventricular arrhythmias.en
- dc.description.sponsorship This work was supported by the Spanish Ministry of Economy and Competitiveness under the Maria de Maeztu Units of Excellence Programme [MDM-2015-0502].
- dc.format.mimetype application/pdf
- dc.identifier.citation Doste R, Sebastian R, Gomez JF, Soto-Iglesias D, Alcaine A, Mont L, Berruezo A, Penela D, Camara O. In silico pace-mapping: prediction of left vs. right outflow tract origin in idiopathic ventricular arrhythmias with patient-specific electrophysiological simulations. Europace. 2020 Jul 1;22(9):1419-30. DOI: 10.1093/europace/euaa102
- dc.identifier.doi http://dx.doi.org/10.1093/europace/euaa102
- dc.identifier.issn 1099-5129
- dc.identifier.uri http://hdl.handle.net/10230/46078
- dc.language.iso eng
- dc.publisher Oxford University Press
- dc.relation.ispartof Europace. 2020 Jul 1;22(9):1419-30
- dc.rights © Oxford University Press. This is a pre-copyedited, author-produced version of an article accepted for publication in In silico pace-mapping: prediction of left vs. right outflow tract origin in idiopathic ventricular arrhythmias with patient-specific electrophysiological simulations following peer review. The version of record Doste R, Sebastian R, Gomez JF, Soto-Iglesias D, Alcaine A, Mont L, Berruezo A, Penela D, Camara O. In silico pace-mapping: prediction of left vs. right outflow tract origin in idiopathic ventricular arrhythmias with patient-specific electrophysiological simulations. Europace. 2020 Jul 1;22(9):1419-30 is available online at: https://doi.org/10.1093/europace/euaa102
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword In silico pace-mappingen
- dc.subject.keyword Radiofrequency ablationen
- dc.subject.keyword Electrophysiological simulationsen
- dc.subject.keyword Outflow tract ventricular arrhythmiaen
- dc.title In silico pace-mapping: prediction of left vs. right outflow tract origin in idiopathic ventricular arrhythmias with patient-specific electrophysiological simulationsen
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion