Cord blood cardiovascular biomarkers in left-sided congenital heart disease
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- dc.contributor.author Bijnens, Bart
- dc.contributor.author Soveral, Iris
- dc.contributor.author Guirado, Laura
- dc.contributor.author Escobar-Diaz, Maria C.
- dc.contributor.author Alcaide, María José
- dc.contributor.author Martínez, Josep Maria
- dc.contributor.author Rodríguez-Sureda, Víctor
- dc.contributor.author Antolin, Eugenia
- dc.contributor.author Llurba, Elisa
- dc.contributor.author Bartha, Jose L.
- dc.contributor.author Gómez, Olga
- dc.contributor.author Crispi Brillas, Fàtima
- dc.date.accessioned 2025-10-20T06:19:52Z
- dc.date.available 2025-10-20T06:19:52Z
- dc.date.issued 2022
- dc.description.abstract Fetal echocardiography has limited prognostic ability in the evaluation of left-sided congenital heart defects (left heart defects). Cord blood cardiovascular biomarkers could improve the prognostic evaluation of left heart defects. A multicenter prospective cohort (2013–2019) including fetuses with left heart defects (aortic coarctation, aortic stenosis, hypoplastic left heart, and multilevel obstruction (complex left heart defects) subdivided according to their outcome (favorable vs. poor), and control fetuses were evaluated in the third trimester of pregnancy at three referral centers in Spain. Poor outcome was defined as univentricular palliation, heart transplant, or death. Cord blood concentrations of N-terminal precursor of B-type natriuretic peptide, Troponin I, transforming growth factor β, placental growth factor, and soluble fms-like tyrosine kinase-1 were determined. A total of 45 fetuses with left heart defects (29 favorable and 16 poor outcomes) and 35 normal fetuses were included, with a median follow-up of 3.1 years (interquartile range 1.4–3.9). Left heart defects with favorable outcome showed markedly increased cord blood transforming growth factor β (normal heart median 15.5 ng/mL (6.8–21.4) vs. favorable outcome 51.7 ng/mL (13.8–73.9) vs. poor outcome 25.1 ng/mL (6.9–39.0), p = 0.001) and decreased placental growth factor concentrations (normal heart 17.9 pg/mL (13.8–23.9) vs. favorable outcome 12.8 pg/mL (11.7–13.6) vs. poor outcome 11.0 pg/mL (8.8–15.4), p < 0.001). Poor outcome left heart defects had higher N-terminal precursor of B-type natriuretic peptide (normal heart 508.0 pg/mL (287.5–776.3) vs. favorable outcome 617.0 pg/mL (389.8–1087.8) vs. poor outcome 1450.0 pg/mL (919.0–1645.0), p = 0.001) and drastically reduced soluble fms-like tyrosine kinase-1 concentrations (normal heart 1929.7 pg/mL (1364.3–2715.8) vs. favorable outcome (1848.3 pg/mL (646.9–2313.6) vs. poor outcome 259.0 pg/mL (182.0–606.0), p < 0.001). Results showed that fetuses with left heart defects present a distinct cord blood biomarker profile according to their outcome.en
- dc.format.mimetype application/pdf
- dc.identifier.citation Soveral I, Guirado L, Escobar-Diaz MC, Alcaide MJ, Martínez JM, Rodríguez-Sureda V, et al. Cord blood cardiovascular biomarkers in left-sided congenital heart disease. J Clin Med. 2022 Nov 30;11(23):7119. DOI: 10.3390/jcm11237119
- dc.identifier.doi http://dx.doi.org/10.3390/jcm11237119
- dc.identifier.issn 2077-0383
- dc.identifier.uri http://hdl.handle.net/10230/71557
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Journal Clinical Medicine. 2022 Nov 30;11(23):7119
- dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Congenital heart defectsen
- dc.subject.keyword Fetal echocardiographyen
- dc.subject.keyword B-type natriuretic peptideen
- dc.subject.keyword Transforming growth factor betaen
- dc.subject.keyword Aortic stenosisen
- dc.subject.keyword Aortic coarctationen
- dc.subject.keyword Hypoplastic left heart syndromeen
- dc.subject.keyword Angiogenic factorsen
- dc.subject.keyword Fetal cardiac remodelingen
- dc.title Cord blood cardiovascular biomarkers in left-sided congenital heart diseaseen
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion