Effect of applied voltage, duration and repetition frequency of RF pulses for pain relief on temperature spikes and electrical field: a computer modeling study
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- dc.contributor.author Ivorra Cano, Antoni, 1974-ca
- dc.contributor.author Ewertowska, Elżbietaca
- dc.contributor.author Mercadal, Borjaca
- dc.contributor.author Muñoz, Víctorca
- dc.contributor.author Trujillo Guillén, Macarenaca
- dc.contributor.author Berjano, Enrique J.ca
- dc.date.accessioned 2017-04-27T14:17:36Z
- dc.date.issued 2018
- dc.description.abstract Background: The thermal and electrical effects of pulsed radiofrequency (PRF) for pain relief can be controlled by modifying the characteristics of the RF pulses applied. Our goal was to evaluate the influence of such modifications on the thermal and electric performance in tissue. Methods: A computational model was developed to compare the temperature and electric field time courses in tissue between a standard clinical protocol (45 V pulses, 20 ms duration, 2 Hz repetition frequency) and a new protocol (55 V pulses, 5 ms duration, 5 Hz repetition frequency) with a higher applied electric field but a smaller impact on temperature alterations in tissue. The effect of including a temperature controller was assessed. Complementarily, an agar-based experimental model was developed to validate the methodology employed in the computer modeling. Results: The new protocol increased the electric field magnitude reached in the tissue by around +20%, without increasing the temperature. The temperature controller was found to be the fundamental factor in avoiding thermal damage to the tissue and reduced the total number of pulses delivered by around 67%. The experimental results matched moderately well with those obtained from a computer model built especially to mimic the experimental conditions. Conclusions: For the same delivered energy, the new protocol significantly increases the magnitude of the applied electric field, which may be the reason why it is clinically more effective in achieving pain relief.en
- dc.format.mimetype application/pdfca
- dc.identifier.citation Ewertowska E, Mercadal B, Muñoz V, Ivorra A, Trujillo M, Berjano E. Effect of applied voltage, duration and repetition frequency of RF pulses for pain relief on temperature spikes and electrical field: a computer modeling study. Int J Hyperthermia. 2018;34(1): 112-21. DOI: 10.1080/02656736.2017.1323122
- dc.identifier.doi http://dx.doi.org/10.1080/02656736.2017.1323122
- dc.identifier.issn 0265-6736
- dc.identifier.uri http://hdl.handle.net/10230/30922
- dc.language.iso eng
- dc.publisher Taylor & Francis (Routledge)ca
- dc.relation.ispartof International Journal of Hyperthermia. 2017. 2018;34(1):112-21
- dc.rights © Taylor & Francis. This is an electronic version of an article published in [include the complete citation information for the final version of the article as published in the print edition of the journal]. International Journal of Hyperthermia is available online at: http://www.tandfonline.com/doi/abs/10.1080/02656736.2017.1323122
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Computational modelen
- dc.subject.keyword Electroporationen
- dc.subject.keyword Pain reliefen
- dc.subject.keyword Pulsed radiofrequencyen
- dc.subject.keyword Temperature spikeen
- dc.title Effect of applied voltage, duration and repetition frequency of RF pulses for pain relief on temperature spikes and electrical field: a computer modeling studyca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion