Exploring mechanisms of spontaneous functional connectivity in MEG:/nHow delayed network interactions lead to structured amplitude/nenvelopes of band-pass filtered oscillations

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dc.contributor.authorCabral, Joanaca
dc.contributor.authorLuckhoo, Henryca
dc.contributor.authorWoolrich, Mark W.ca
dc.contributor.authorJoensson, Mortenca
dc.contributor.authorMohseni, Hamidca
dc.contributor.authorBaker, Adamca
dc.contributor.authorKringelbach, Morten L.ca
dc.contributor.authorDeco, Gustavoca
dc.date.accessioned2015-01-29T08:21:06Z
dc.date.available2015-01-29T08:21:06Z
dc.date.issued2014ca
dc.description.abstractSpontaneous (or resting-state) brain activity has attracted a growing body of neuroimaging research over the last/ndecades.Whole-brain networkmodels have proved helpful to investigate the source of slow(b0.1 Hz) correlated/nhemodynamic fluctuations revealed in fMRI during rest. However, the mechanisms mediating resting-state/nlong-distance correlations and the relationship with the faster neural activity remain unclear. Novel insights/ncoming from MEG studies have shown that the amplitude envelopes of alpha- and beta-frequency oscillations/n(8–30 Hz) display similar correlation patterns as the fMRI signals./nIn thiswork, we combine experimental and theoreticalwork to investigate the mechanisms of spontaneousMEG/nfunctional connectivity. Using a simple model of coupled oscillators adapted to incorporate realisticwhole-brain/nconnectivity and conduction delays, we explore how slow and structured amplitude envelopes of band-pass/nfiltered signals – fairly reproducing MEG data collected from 10 healthy subjects at rest – are generated spontaneously/nin the space-time structure of the brain network./nOur simulation results show that the large-scale neuroanatomical connectivity provides an optimal network/nstructure to support a regimewith metastable synchronization. In this regime, different subsystems may temporarily/nsynchronize at reduced collective frequencies (falling in the 8–30 Hz range due to the delays) while the/nglobal system never fully synchronizes. This mechanism modulates the frequency of the oscillators on a slow/ntime-scale (b0.1 Hz) leading to structured amplitude fluctuations of band-pass filtered signals. Taken overall,/nour results reveal that the structured amplitude envelope fluctuations observed in resting-state MEG data may/noriginate from spontaneous synchronization mechanisms naturally occurring in the space-time structure of/nthe brain.en
dc.description.sponsorshipThe research reported herein was supported by the ERC Advanced/nGrant: DYSTRUCTURE (n. 295129), by the FET Flagship Human Brain/nProject, by the Spanish Research Project SAF2010-16085, by the/nCONSOLIDER-INGENIO 2010 CSD2007-00012, by the BrainNRG through/nthe James S. McDonnell Foundation, by the FP7-ICT BrainScales, by the/nRCUK Digital Economy – Centre for Doctoral Training in Healthcare/nInnovation, by theMINDLab Investment Capital for University Research/nFund and by the TrygFonden Charitable Foundation.en
dc.format.extent13 p.
dc.format.mimetypeapplication/pdfca
dc.identifier.citationCabral J, Luckhoo H, Woolrich M, Joensson M, Mohseni H, Baker A, Kringelbach ML, Deco G. Exploring mechanisms of spontaneous functional connectivity in MEG: How delayed network interactions lead to structured amplitude envelopes of band-pass filtered oscillations. Neuroimage. 2014 Apr;90:423-35. DOI 10.1016/j.neuroimage.2013.11.047ca
dc.identifier.doihttp://dx.doi.org/10.1016/j.neuroimage.2013.11.047
dc.identifier.issn1053-8119ca
dc.identifier.urihttp://hdl.handle.net/10230/23081
dc.language.isoengca
dc.publisherElsevierca
dc.relation.ispartofNeuroimage. 2014 Apr;90:423-35
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/295129ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/269921
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/3PN/SAF2010-16085
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2PN/CSD2007-00012
dc.rights© 2013 The Authors. Published by Elsevier Inc. Open access under CC-BY-NC-ND Licenseca
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.keywordResting stateen
dc.subject.keywordMEGen
dc.subject.keywordOscillationsen
dc.subject.keywordNetworken
dc.subject.keywordKuramotoen
dc.subject.keywordModelingen
dc.subject.keywordStructural connectivityen
dc.subject.keywordFunctional connectivityen
dc.titleExploring mechanisms of spontaneous functional connectivity in MEG:/nHow delayed network interactions lead to structured amplitude/nenvelopes of band-pass filtered oscillationsca
dc.typeinfo:eu-repo/semantics/articleca
dc.type.versioninfo:eu-repo/semantics/publishedVersionca

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