Exploring mechanisms of spontaneous functional connectivity in MEG:/nHow delayed network interactions lead to structured amplitude/nenvelopes of band-pass filtered oscillations

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Cabral, Joanaca
• dc.contributor.author Luckhoo, Henryca
• dc.contributor.author Woolrich, Mark W.ca
• dc.contributor.author Joensson, Mortenca
• dc.contributor.author Mohseni, Hamidca
• dc.contributor.author Baker, Adamca
• dc.contributor.author Kringelbach, Morten L.ca
• dc.contributor.author Deco, Gustavoca
• dc.date.accessioned 2015-01-29T08:21:06Z
• dc.date.available 2015-01-29T08:21:06Z
• dc.date.issued 2014ca
• dc.description.abstract Spontaneous (or resting-state) brain activity has attracted a growing body of neuroimaging research over the last/ndecades.Whole-brain networkmodels have proved helpful to investigate the source of slow(b0.1 Hz) correlated/nhemodynamic fluctuations revealed in fMRI during rest. However, the mechanisms mediating resting-state/nlong-distance correlations and the relationship with the faster neural activity remain unclear. Novel insights/ncoming from MEG studies have shown that the amplitude envelopes of alpha- and beta-frequency oscillations/n(8–30 Hz) display similar correlation patterns as the fMRI signals./nIn thiswork, we combine experimental and theoreticalwork to investigate the mechanisms of spontaneousMEG/nfunctional connectivity. Using a simple model of coupled oscillators adapted to incorporate realisticwhole-brain/nconnectivity and conduction delays, we explore how slow and structured amplitude envelopes of band-pass/nfiltered signals – fairly reproducing MEG data collected from 10 healthy subjects at rest – are generated spontaneously/nin the space-time structure of the brain network./nOur simulation results show that the large-scale neuroanatomical connectivity provides an optimal network/nstructure to support a regimewith metastable synchronization. In this regime, different subsystems may temporarily/nsynchronize at reduced collective frequencies (falling in the 8–30 Hz range due to the delays) while the/nglobal system never fully synchronizes. This mechanism modulates the frequency of the oscillators on a slow/ntime-scale (b0.1 Hz) leading to structured amplitude fluctuations of band-pass filtered signals. Taken overall,/nour results reveal that the structured amplitude envelope fluctuations observed in resting-state MEG data may/noriginate from spontaneous synchronization mechanisms naturally occurring in the space-time structure of/nthe brain.en
• dc.description.sponsorship The research reported herein was supported by the ERC Advanced/nGrant: DYSTRUCTURE (n. 295129), by the FET Flagship Human Brain/nProject, by the Spanish Research Project SAF2010-16085, by the/nCONSOLIDER-INGENIO 2010 CSD2007-00012, by the BrainNRG through/nthe James S. McDonnell Foundation, by the FP7-ICT BrainScales, by the/nRCUK Digital Economy – Centre for Doctoral Training in Healthcare/nInnovation, by theMINDLab Investment Capital for University Research/nFund and by the TrygFonden Charitable Foundation.en
• dc.format.extent 13 p.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Cabral J, Luckhoo H, Woolrich M, Joensson M, Mohseni H, Baker A, Kringelbach ML, Deco G. Exploring mechanisms of spontaneous functional connectivity in MEG: How delayed network interactions lead to structured amplitude envelopes of band-pass filtered oscillations. Neuroimage. 2014 Apr;90:423-35. DOI 10.1016/j.neuroimage.2013.11.047ca
• dc.identifier.doi http://dx.doi.org/10.1016/j.neuroimage.2013.11.047
• dc.identifier.issn 1053-8119ca
• dc.identifier.uri http://hdl.handle.net/10230/23081
• dc.language.iso engca
• dc.publisher Elsevierca
• dc.relation.ispartof Neuroimage. 2014 Apr;90:423-35
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/295129ca
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/269921
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2010-16085
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/CSD2007-00012
• dc.rights © 2013 The Authors. Published by Elsevier Inc. Open access under CC-BY-NC-ND Licenseca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/
• dc.subject.keyword Resting stateen
• dc.subject.keyword MEGen
• dc.subject.keyword Oscillationsen
• dc.subject.keyword Networken
• dc.subject.keyword Kuramotoen
• dc.subject.keyword Modelingen
• dc.subject.keyword Structural connectivityen
• dc.subject.keyword Functional connectivityen
• dc.title Exploring mechanisms of spontaneous functional connectivity in MEG:/nHow delayed network interactions lead to structured amplitude/nenvelopes of band-pass filtered oscillationsca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca