Overview on cognitive impairment in psychotic disorders: from impaired microcircuits to dysconnectivity

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  • dc.contributor.author Mana, Ludovica
  • dc.contributor.author Schwartz-Pallejà, Marc
  • dc.contributor.author Vila-Vidal, Manel, 1991-
  • dc.contributor.author Deco, Gustavo
  • dc.date.accessioned 2025-06-27T07:16:23Z
  • dc.date.available 2025-06-27T07:16:23Z
  • dc.date.issued 2024
  • dc.description.abstract Schizophrenia's cognitive deficits, often overshadowed by positive symptoms, significantly contribute to the disorder's morbidity. Increasing attention highlights these deficits as reflections of neural circuit dysfunction across various cortical regions. Numerous connectivity alterations linked to cognitive symptoms in psychotic disorders have been reported, both at the macroscopic and microscopic level, emphasizing the potential role of plasticity and microcircuits impairment during development and later stages. However, the heterogeneous clinical presentation of cognitive impairment and diverse connectivity findings pose challenges in summarizing them into a cohesive picture. This review aims to synthesize major cognitive alterations, recent insights into network structural and functional connectivity changes and proposed mechanisms and microcircuit alterations underpinning these symptoms, particularly focusing on neurodevelopmental impairment, E/I balance, and sleep disturbances. Finally, we will also comment on some of the most recent and promising therapeutic approaches that aim to target these mechanisms to address cognitive symptoms. Through this comprehensive exploration, we strive to provide an updated and nuanced overview of the multiscale connectivity impairment underlying cognitive impairment in psychotic disorders.
  • dc.description.sponsorship The project that gave rise to these results received the support of a fellowship from “la Caixa” foundation “(ID 100010434)”. The fellowship code is: “(LCF/BQ/DI19/11730048)”, and financed L.M. work. M.S. is a fellow of Eurecat's “Vicente López” PhD grant program. M.V.V. was supported by the Grant/Award Number: PID2020-119072RA-I00/AEI/10.13039/501100011033 financed by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI). This last institution also financed M.V.V trough the Grant/Award Number: PID2020-119072RA-I00/AEI/10.13039/501100011033. G.D. was supported by the project NEurological MEchanismS of Injury, and Sleep-like cellular dynamics (NEMESIS) (ref. 101071900) funded by the EU ERC Synergy Horizon Europe, by the NODYN Project PID2022-136216NB-I00 financed by the MCIN/AEI/10.13039/501100011033/FEDER, UE., the Ministry of Science and Innovation, the Spanish State Research Agency and the European Regional Development Fund, by the AGAUR research support grant (ref. 2021 SGR 00917) funded by the Department of Research and Universities of the Generalitat de Catalunya, and by the project eBRAIN-Health - Actionable Multilevel Health Data (id 101058516), funded by the EU Horizon Europe.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Mana L, Schwartz-Pallejà M, Vila-Vidal M, Deco G. Overview on cognitive impairment in psychotic disorders: from impaired microcircuits to dysconnectivity. Schizophr Res. 2024 July;269:132-43. DOI: 10.1016/j.schres.2024.05.008
  • dc.identifier.doi http://dx.doi.org/10.1016/j.schres.2024.05.008
  • dc.identifier.issn 0920-9964
  • dc.identifier.uri http://hdl.handle.net/10230/70778
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Schizophrenia Research. 2024 July;269:132-43
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101071900
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-119072RA-I00
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2022-136216NB-I00
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101058516
  • dc.rights © 2024 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
  • dc.subject.keyword Psychotic disorders
  • dc.subject.keyword Brain connectivity
  • dc.subject.keyword Excitation-inhibition balance
  • dc.subject.keyword Neurodevelopmental impairments
  • dc.subject.keyword Spindle
  • dc.subject.keyword Cognitive therapies
  • dc.title Overview on cognitive impairment in psychotic disorders: from impaired microcircuits to dysconnectivity
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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