Time-resolved gene expression profiling during reprogramming of C/EBPα-pulsed B cells into iPS cells
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- dc.contributor.author Di Stefano, Bruno, 1984-
- dc.contributor.author Collombet, Samuel
- dc.contributor.author Graf, T. (Thomas)
- dc.date.accessioned 2023-12-18T09:46:47Z
- dc.date.available 2023-12-18T09:46:47Z
- dc.date.issued 2014
- dc.description.abstract The reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) is lengthy and inefficient. The development of a reprogramming system that allows rapid and synchronous reprogramming to pluripotency is imperative for understanding the mechanism of iPSC formation and for future therapeutic applications. We have recently reported that a short expression in mouse primary B cells of the transcription factor C/EBPα before the induction of pluripotency factors increases the iPSC reprogramming efficiency >100-fold, involving 95% of the cells within a week. Here we present a dataset containing the time course of gene expression during this process as determined by microarray and RNA-seq techniques.
- dc.format.mimetype application/pdf
- dc.identifier.citation Di Stefano B, Collombet S, Graf T. Time-resolved gene expression profiling during reprogramming of C/EBPα-pulsed B cells into iPS cells. Sci Data. 2014 May 27;1(1):140008. DOI: 10.1038/sdata.2014.8
- dc.identifier.doi http://dx.doi.org/10.1038/sdata.2014.8
- dc.identifier.issn 2052-4463
- dc.identifier.uri http://hdl.handle.net/10230/58566
- dc.language.iso eng
- dc.publisher Nature Research
- dc.relation.ispartof Scientific Data. 2014 May 27;1(1):140008
- dc.rights This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc/3.0/ Metadata associated with this Data Descriptor is available at http://www.nature.com/sdata/ and is released under the CC0 waiver to maximize reuse.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0/
- dc.subject.other Cèl·lules mare
- dc.subject.other Cèl·lules
- dc.subject.other Genètica
- dc.title Time-resolved gene expression profiling during reprogramming of C/EBPα-pulsed B cells into iPS cells
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion