Insights into insulin resistance and calcification in the Myocardium in type 2 dDiabetes: a coronary artery analysis

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Martín-Saladich, Queralt
• dc.contributor.author Simó, Rafael
• dc.contributor.author Aguadé-Bruix, Santiago
• dc.contributor.author Simó-Servat, Olga
• dc.contributor.author Aparicio-Gómez, Carolina
• dc.contributor.author Hernández, Cristina
• dc.contributor.author Ramirez-Serra, Clara
• dc.contributor.author Nazarena Pizzi, María
• dc.contributor.author Roque, Albert
• dc.contributor.author González Ballester, Miguel Ángel, 1973-
• dc.contributor.author Herance Camacho, José Raul
• dc.date.accessioned 2023-06-20T06:23:29Z
• dc.date.available 2023-06-20T06:23:29Z
• dc.date.issued 2023
• dc.description.abstract Type 2 diabetes (T2D) is responsible for high incidence of cardiovascular (CV) complications leading to heart failure. Coronary artery region-specific metabolic and structural assessment could provide deeper insight into the extent of the disease and help prevent adverse cardiac events. Therefore, in this study, we aimed at investigating such myocardial dynamics for the first time in insulin-sensitive (mIS) and insulin-resistant (mIR) T2D patients. We targeted global and region-specific variations using insulin sensitivity (IS) and coronary artery calcifications (CACs) as CV risk factor in T2D patients. IS was computed using myocardial segmentation approaches at both baseline and after an hyperglycemic–insulinemic clamp (HEC) on [18F]FDG-PET images using the standardized uptake value (SUV) (ΔSUV = SUVHEC − SUVBASELINE) and calcifications using CT Calcium Scoring. Results suggest that some communicating pathways between response to insulin and calcification are present in the myocardium, whilst differences between coronary arteries were only observed in the mIS cohort. Risk indicators were mostly observed for mIR and highly calcified subjects, which supports previously stated findings that exhibit a distinguished exposure depending on the impairment of response to insulin, while projecting added potential complications due to arterial obstruction. Moreover, a pattern relating calcification and T2D phenotypes was observed suggesting the avoidance of insulin treatment in mIS but its endorsement in mIR subjects. The right coronary artery displayed more ΔSUV, whilst plaque was more present in the circumflex. However, differences between phenotypes, and therefore CV risk, were associated to left descending artery (LAD) translating into higher CACs regarding IR, which could explain why insulin treatment was effective for LAD at the expense of higher likelihood of plaque accumulation. Personalized approaches to assess T2D may lead to more efficient treatments and risk-prevention strategies.
• dc.format.mimetype application/pdf
• dc.identifier.citation Martín-Saladich Q, Simó R, Aguadé-Bruix S, Simó-Servat O, Aparicio-Gómez C, Hernández C, et al. Insights into insulin resistance and calcification in the Myocardium in type 2 dDiabetes: a coronary artery analysis. IJMS. 2023 Feb 2;24(4):3250. DOI: 10.3390/ijms24043250
• dc.identifier.doi http://dx.doi.org/10.3390/ijms24043250
• dc.identifier.issn 1661-6596
• dc.identifier.uri http://hdl.handle.net/10230/57256
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof International Journal of Molecular Sciences. 2023 Feb 2;24(4):3250
• dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Myocardium
• dc.subject.keyword Insulin sensibility
• dc.subject.keyword Type 2 diabetes
• dc.subject.keyword [18F]FDG-PET imaging
• dc.subject.keyword Cardiovascular risk
• dc.subject.keyword Coronary artery
• dc.subject.keyword Metabolic disease
• dc.subject.keyword Computed tomography
• dc.subject.keyword Calcification
• dc.title Insights into insulin resistance and calcification in the Myocardium in type 2 dDiabetes: a coronary artery analysis
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion