Meditation-induced effects on whole-brain structural and effective connectivity

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• dc.contributor.author De Filippi, Eleonora
• dc.contributor.author Escrichs, Anira
• dc.contributor.author Càmara, Estela
• dc.contributor.author Garrido, César
• dc.contributor.author Marins, Theo
• dc.contributor.author Sánchez Fibla, Martí
• dc.contributor.author Gilson, Matthieu
• dc.contributor.author Deco, Gustavo
• dc.date.accessioned 2023-03-08T07:25:27Z
• dc.date.available 2023-03-08T07:25:27Z
• dc.date.issued 2022
• dc.description.abstract In the past decades, there has been a growing scientific interest in characterizing neural correlates of meditation training. Nonetheless, the mechanisms underlying meditation remain elusive. In the present work, we investigated meditation-related changes in functional dynamics and structural connectivity (SC). For this purpose, we scanned experienced meditators and control (naive) subjects using magnetic resonance imaging (MRI) to acquire structural and functional data during two conditions, resting-state and meditation (focused attention on breathing). In this way, we aimed to characterize and distinguish both short-term and long-term modifications in the brain’s structure and function. First, to analyze the fMRI data, we calculated whole-brain effective connectivity (EC) estimates, relying on a dynamical network model to replicate BOLD signals’ spatio-temporal structure, akin to functional connectivity (FC) with lagged correlations. We compared the estimated EC, FC, and SC links as features to train classifiers to predict behavioral conditions and group identity. Then, we performed a network-based analysis of anatomical connectivity. We demonstrated through a machine-learning approach that EC features were more informative than FC and SC solely. We showed that the most informative EC links that discriminated between meditators and controls involved several large-scale networks mainly within the left hemisphere. Moreover, we found that differences in the functional domain were reflected to a smaller extent in changes at the anatomical level as well. The network-based analysis of anatomical pathways revealed strengthened connectivity for meditators compared to controls between four areas in the left hemisphere belonging to the somatomotor, dorsal attention, subcortical and visual networks. Overall, the results of our whole-brain model-based approach revealed a mechanism underlying meditation by providing causal relationships at the structure-function level.
• dc.description.sponsorship Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. EDF is supported by the Doctorate Scholarship FI-2020 from the Catalan Agency for Management of University and Research Grants (AGAUR). AE is supported by the HBP SGA3 Human Brain Project Specific Grant Agreement 3 (grant agreement no. 945539), funded by the EU H2020 FET Flagship programme and by a Francisco J. Varela Award from the Mind and Life Europe. TM is supported by the Foundation for Research Support in the State of Rio de Janeiro (FAPERJ) and the D’Or Institute for Research and Education (IDOR). MG acknowledges funding from the German Excellence Strategy of the Federal Government and the Länder (G:(DE-82)EXS-PF-JARA-SDS005) and the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 785907 (Human Brain Project SGA2). MSF is supported by the Spanish Ministry of Economy and Competitiveness (MINECO) grant (INSOCO-DPI2016-80116-P). GD is supported by the Spanish national research project AWAKENING (ref. PID2019-105772GB-I00/AEI/10.13039/501100011033) funded by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI), by the HBP SGA3 Human Brain Project Specific Grant Agreement 3 (grant agreement no. 945539), funded by the EU H2020 FET Flagship programme, and by the SGR Research Support Group support (ref. 2017 SGR 1545), funded by the Catalan Agency for Management of University and Research Grants (AGAUR).
• dc.format.mimetype application/pdf
• dc.identifier.citation de Filippi E, Escrichs A, Càmara E, Garrido C, Marins T, Sánchez‑Fibla M, Gilson M, Deco G. Meditation-induced effects on whole-brain structural and effective connectivity. Brain Struct Funct. 2022;227(6):2087-102. DOI: 10.1007/s00429-022-02496-9
• dc.identifier.doi http://dx.doi.org/10.1007/s00429-022-02496-9
• dc.identifier.issn 1863-2653
• dc.identifier.uri http://hdl.handle.net/10230/56105
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof Brain Structure and Function. 2022;227(6):2087-102.
• dc.relation.isreferencedby https://github.com/MatthieuGilson/WBLEC_toolbox
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/785907
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/DPI2016-80116-P
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-105772GB-I00
• dc.rights © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Meditation
• dc.subject.keyword Resting-state
• dc.subject.keyword fMRI
• dc.subject.keyword Whole-brain modeling
• dc.subject.keyword Efective connectivity
• dc.subject.keyword Structural connectivity
• dc.title Meditation-induced effects on whole-brain structural and effective connectivity
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion