Distribution of myocardial work in arterial hypertension: insights from non-invasive left ventricular pressure-strain relations
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- dc.contributor.author Loncaric, Filip
- dc.contributor.author Marciniak, Maciej
- dc.contributor.author Nunno, Loredana
- dc.contributor.author Mimbrero, Maria
- dc.contributor.author Fernandes, João, 1964-
- dc.contributor.author Fabijanovic, Dora
- dc.contributor.author Sanchis, Laura
- dc.contributor.author Doltra, Adelina
- dc.contributor.author Montserrat, Silvia
- dc.contributor.author Cikes, Maja
- dc.contributor.author Lamata, Pablo
- dc.contributor.author Bijnens, Bart
- dc.contributor.author Sitges, Marta
- dc.date.accessioned 2020-12-11T08:56:58Z
- dc.date.issued 2020
- dc.description.abstract A index of non-invasive myocardial work (MWI) can account for pressure during the assessment of cardiac function, potentially separating the influence of loading conditions from the influence of the underlying tissue remodelling. The aim is to assess LV function accounted for loading and explore hypertensive MWI distribution by comparing healthy individuals to hypertensive patients without and with localized basal septal hypertrophy (BSH). An echocardiogram was performed in 170 hypertensive patients and 20 healthy individuals. BSH was defined by a basal-to-mid septal wall thickness ratio ≥ 1.4. LV speckle-tracking was performed, and the MWI calculated globally and regionally for the apical, mid and basal regions. An apex-to-base gradient, seen in regional strain values, was preserved in the distribution of myocardial work, with the apical region compensating for the impairment of the basal segments. This functional redistribution was further pronounced in patients with localized BSH. In these patients, segmental MWI analysis revealed underlying impairment of regional work unrelated to acute loading conditions. Non-invasive MWI analysis offers the possibility to compare LV function regardless of blood pressure at the time of observation. Changes in MWI distribution can be seen in hypertension unrelated to the load-dependency of strain. Accentuated functional changes affirm the role of BSH as an echocardiographic marker in hypertension.en
- dc.description.sponsorship This work was supported by Horizon 2020 European Commission Project H2020-MSCA-ITN-2016 (764738), Grant from Fundacio La Marató de TV3 (040310, Exp 2015.40.30), and from Fondo de Investigaciones Sanitarias - Instituto de Salud Carlos III (PI17/01131). PL holds a Wellcome Trust Senior Research Fellowship (209450/Z/17/Z).
- dc.format.mimetype application/pdf
- dc.identifier.citation Loncaric F, Marciniak M, Nunno L, Mimbrero M, Fernandes JF, Fabijanovic D, Sanchis L, Doltra, Montserrat S, Cikes M, Lamata P, Bijnens B, Sitges M. Distribution of myocardial work in arterial hypertension: insights from non-invasive left ventricular pressure-strain relations. Int J Cardiovasc Imaging. 2020 Aug 12. DOI: 10.1007/s10554-020-01969-4
- dc.identifier.doi http://dx.doi.org/10.1007/s10554-020-01969-4
- dc.identifier.issn 1569-5794
- dc.identifier.uri http://hdl.handle.net/10230/46001
- dc.language.iso eng
- dc.publisher Springer
- dc.relation.ispartof The International Journal of Cardiovascular Imaging. 2020 Aug 12
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/764738
- dc.rights © Springer The final publication is available at Springer via http://dx.doi.org/10.1007/s10554-020-01969-4
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Hypertensionen
- dc.subject.keyword Remodelingen
- dc.subject.keyword Myocardial worken
- dc.subject.keyword Basal septal hypertrophyen
- dc.subject.keyword Speckle trackingen
- dc.title Distribution of myocardial work in arterial hypertension: insights from non-invasive left ventricular pressure-strain relationsen
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion