IntOGen-mutations identifies cancer drivers across tumor types

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• dc.contributor.author Gonzalez-Perez, Abel
• dc.contributor.author Pérez Llamas, Christian, 1976
• dc.contributor.author Deu Pons, Jordi
• dc.contributor.author Tamborero Noguera, David
• dc.contributor.author Schroeder, Michael Philipp,1986-
• dc.contributor.author Jené i Sanz, Alba, 1984-
• dc.contributor.author Santos, Alberto
• dc.contributor.author López Bigas, Núria
• dc.date.accessioned 2024-01-22T06:45:32Z
• dc.date.available 2024-01-22T06:45:32Z
• dc.date.issued 2013
• dc.description Includes supplementary materials for the online appendix.
• dc.description.abstract The IntOGen-mutations platform (http://www.intogen.org/mutations/) summarizes somatic mutations, genes and pathways involved in tumorigenesis. It identifies and visualizes cancer drivers, analyzing 4,623 exomes from 13 cancer sites. It provides support to cancer researchers, aids the identification of drivers across tumor cohorts and helps rank mutations for better clinical decision-making.
• dc.description.sponsorship We acknowledge funding from the Spanish Ministry of Economy and Competitivity (grants SAF2009-06954 and SAF2012-36199) and the Spanish National Institute of Bioinformatics (INB). We gratefully acknowledge contributions from the TCGA Research Network and its TCGA Pan-Cancer Analysis Working Group (contributing consortium members are listed in Supplementary Note 5). The TCGA Pan-Cancer Analysis Working Group is coordinated by J.M. Stuart, C. Sander and I. Shmulevich. We are also grateful to the ICGC for the tumor genome resequencing data generated.
• dc.format.mimetype application/pdf
• dc.identifier.citation Gonzalez-Perez A, Perez-Llamas C, Deu-Pons J, Tamborero D, Schroeder MP, Jene-Sanz A, et al. IntOGen-mutations identifies cancer drivers across tumor types. Nat Methods. 2013 Nov;10(11):1081-2. DOI: 10.1038/nmeth.2642
• dc.identifier.doi http://dx.doi.org/10.1038/nmeth.2642
• dc.identifier.issn 1548-7091
• dc.identifier.uri http://hdl.handle.net/10230/58761
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Nature Methods. 2013 Nov;10(11):1081-2
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2009-06954
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-36199
• dc.rights This work is licensed under a Creative Commons AttributionNonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/
• dc.subject.other Càncer
• dc.subject.other Tumors
• dc.subject.other Mutació (Biologia)
• dc.title IntOGen-mutations identifies cancer drivers across tumor types
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion