Human consciousness is supported by dynamic complex patterns of brain signal coordination

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  • dc.contributor.author Demertzi, A.
  • dc.contributor.author Tagliazucchi, Enzo
  • dc.contributor.author Dehaene, Stanislas
  • dc.contributor.author Deco, Gustavo
  • dc.contributor.author Barttfeld, P.
  • dc.contributor.author Raimondo, F.
  • dc.contributor.author Martial, Charlotte
  • dc.contributor.author Fernández-Espejo, D.
  • dc.contributor.author Rohaut, B.
  • dc.contributor.author Voss, H. U.
  • dc.contributor.author Schiff, N. D.
  • dc.contributor.author Owen, A. M.
  • dc.contributor.author Laureys, Steven
  • dc.contributor.author Naccache, Lionel
  • dc.contributor.author Sitt, J. D.
  • dc.date.accessioned 2019-08-01T07:46:50Z
  • dc.date.available 2019-08-01T07:46:50Z
  • dc.date.issued 2019
  • dc.description.abstract Adopting the framework of brain dynamics as a cornerstone of human consciousness, we determined whether dynamic signal coordination provides specific and generalizable patterns pertaining to conscious and unconscious states after brain damage. A dynamic pattern of coordinated and anticoordinated functional magnetic resonance imaging signals characterized healthy individuals and minimally conscious patients. The brains of unresponsive patients showed primarily a pattern of low interareal phase coherence mainly mediated by structural connectivity, and had smaller chances to transition between patterns. The complex pattern was further corroborated in patients with covert cognition, who could perform neuroimaging mental imagery tasks, validating this pattern’s implication in consciousness. Anesthesia increased the probability of the less complex pattern to equal levels, validating its implication in unconsciousness. Our results establish that consciousness rests on the brain’s ability to sustain rich brain dynamics and pave the way for determining specific and generalizable fingerprints of conscious and unconscious states.
  • dc.description.sponsorship The reported data have been collected and shared among partners participating in the James S. McDonnell Foundation Collaborative Activity Award “Recovery of Consciousness After Severe Brain Injury” (phases I and II; 2008–2017). This work has been further financially supported by the INSERM, the Belgian National Funds for Scientific Research (FNRS), the Institut du Cerveau et de la Moelle épinière (ICM), the Canada Excellence Research Chairs (CERC) program, the CIFAR Canadian Institute for Advanced Research, the Canadian Institutes of Health Research (CIHR), the European Commission, the Human Brain Project (EU-H2020-FETFLAGSHIP-HBP-SGA1-GA720270), the Luminous project (EU-H2020-fetopen-ga686764), the Center-TBI project (FP7-HEALTH- 602150), the Belgian American Education Foundation, the Wallonie-Bruxelles International, the Fonds Léon Fredericq, “Fondazione Europea di Ricerca Biomedica,” European Space Agency, Belspo, BIAL Foundation, the Mind Science Foundation, the French Speaking Community Concerted Research Action (ARC-06/11-340), and the University and University Hospital of Liège.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Demertzi A, Tagliazucchi E, Dehaene S, Deco G, Barttfeld P, Raimondo F, et al. Human consciousness is supported by dynamic complex patterns of brain signal coordination. Sci Adv. 2019 Feb 1;5(2):eaat7603. DOI: 10.1126/sciadv.aat7603
  • dc.identifier.doi http://dx.doi.org/10.1126/sciadv.aat7603
  • dc.identifier.issn 2375-2548
  • dc.identifier.uri http://hdl.handle.net/10230/42221
  • dc.language.iso eng
  • dc.publisher American Association for the Advancement of Science (AAAS)
  • dc.relation.ispartof Science Advances. 2019 Feb 1;5(2):eaat7603.
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/720270
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/602150
  • dc.rights © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
  • dc.title Human consciousness is supported by dynamic complex patterns of brain signal coordination
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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