Modeling the impact of prostate edema on LDR brachytherapy: a Monte Carlo dosimetry study based on a 3D biphasic finite element biomechanical model

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• dc.contributor.author Mountris, Konstantinos A.
• dc.contributor.author Bert, J.
• dc.contributor.author Noailly, Jérôme
• dc.contributor.author Rodríguez Aguilera, Alejandro
• dc.contributor.author Valeri, Alessandro
• dc.contributor.author Pradier, O.
• dc.contributor.author Schick, U.
• dc.contributor.author Promayon, E.
• dc.contributor.author González Ballester, Miguel Ángel, 1973-
• dc.contributor.author Troccaz, J.
• dc.contributor.author Visvikis, D.
• dc.date.accessioned 2021-06-29T08:10:53Z
• dc.date.available 2021-06-29T08:10:53Z
• dc.date.issued 2017
• dc.description.abstract Prostate volume changes due to edema occurrence during transperineal permanent brachytherapy should be taken under consideration to ensure optimal dose delivery. Available edema models, based on prostate volume observations, face several limitations. Therefore, patient-specific models need to be developed to accurately account for the impact of edema. In this study we present a biomechanical model developed to reproduce edema resolution patterns documented in the literature. Using the biphasic mixture theory and finite element analysis, the proposed model takes into consideration the mechanical properties of the pubic area tissues in the evolution of prostate edema. The model's computed deformations are incorporated in a Monte Carlo simulation to investigate their effect on post-operative dosimetry. The comparison of Day1 and Day30 dosimetry results demonstrates the capability of the proposed model for patient-specific dosimetry improvements, considering the edema dynamics. The proposed model shows excellent ability to reproduce previously described edema resolution patterns and was validated based on previous findings. According to our results, for a prostate volume increase of 10–20% the Day30 urethra D10 dose metric is higher by 4.2%–10.5% compared to the Day1 value. The introduction of the edema dynamics in Day30 dosimetry shows a significant global dose overestimation identified on the conventional static Day30 dosimetry. In conclusion, the proposed edema biomechanical model can improve the treatment planning of transperineal permanent brachytherapy accounting for post-implant dose alterations during the planning procedure.
• dc.description.sponsorship This work was partly supported by the French Brittany Region and by the French ANR within the Investissements d'Avenir program (Labex CAMI) under reference ANR-11-LABX-0004 (Integrated project CAPRI) and through FOCUS project (ANR-16-CE19-0011).
• dc.format.mimetype application/pdf
• dc.identifier.citation Mountris KA, Bert J, Noailly J, Rodriguez Aguilera A, Valeri A, Pradier O, Schick U, Promayon E, González Ballester MA, Troccaz J. Modeling the impact of prostate edema on LDR brachytherapy: a Monte Carlo dosimetry study based on a 3D biphasic finite element biomechanical model. Phys Med Biol. 2017;62(6):2087-102. DOI: 10.1088/1361-6560/aa5d3a
• dc.identifier.doi http://dx.doi.org/10.1088/1361-6560/aa5d3a
• dc.identifier.issn 0031-9155
• dc.identifier.uri http://hdl.handle.net/10230/48001
• dc.language.iso eng
• dc.publisher IOP Publishing Ltd.
• dc.relation.ispartof Physics in Medicine and Biology. 2017;62(6):2087-102
• dc.rights © Institute of Physics (IOP) (10.1088/1361-6560/aa5d3a)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Prostate brachytherapy
• dc.subject.keyword Edema dynamics
• dc.subject.keyword Biomechanical model
• dc.subject.keyword Monte Carlo simulation
• dc.subject.keyword Dynamic dosimetry
• dc.title Modeling the impact of prostate edema on LDR brachytherapy: a Monte Carlo dosimetry study based on a 3D biphasic finite element biomechanical model
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion